Blood-based DNA methylation as biomarker for breast cancer: a systematic review

Tang, Qiuqiong; Cheng, Jie; Cao, Xue; Surowy, Harald; Burwinkel, Barbara

doi:10.1186/s13148-016-0282-6

Clinical Epigenetics

Table 1 Characteristics summary of the 45 eligible studies

From: Blood-based DNA methylation as biomarker for breast cancer: a systematic review

Number	First author	Year	Country	DNA source	Sample treatment	Measurement	Methylation levels available	Odds ratio estimation available
1	Widschwendter M	2008	Germany	Blood	–	Gene-specific methylation	Yes	Yes
2	Snell C	2008	Australia	Blood	–	Gene-specific methylation	Yes	No
3	Ito Y	2008	UK	Blood	–	Gene-specific methylation	Yes	Yes
4	Flanagan. JM	2009	UK	Blood	–	Gene-specific methylation	Yes	Yes
5	Choi JY	2009	USA	Blood	–	Global DNA methylation	Yes	Yes
6	Cho YH	2010	Turkey	Blood	–	Both global DNA methylation and gene-specific methylation	Yes	No
7	Hoffman AE	2010	Connecticut	Blood	–	Gene-specific methylation	No	Yes
8	Wong EM	2011	Australia	Blood	–	Gene-specific methylation	Yes	Yes
9	Iwamoto T	2011	Japan	Blood	–	Gene-specific methylation	Yes	Yes
10	Brennan K	2012	Australia, New Zealand, UK, and Europe	Blood	–	Both global DNA methylation and gene-specific methylation	Yes	Yes
11	Xu X	2012	USA	Blood	–	Global DNA methylation	Yes	Yes
12	Bosviel R	2012	France	Blood	–	Gene-specific methylation	Yes	No
13	Wu HC	2012	USA	Blood	–	Global DNA methylation	Yes	Yes
14	Delgado-Cruzata L	2012	USA	Blood	–	Global DNA methylation	Yes	Yes
15	Kitkumthorn N	2012	Thailand	Blood	–	Global DNA methylation	Yes	No
16	Hajikhan Mirzaei M	2012	Iran	Blood	–	Gene-specific methylation	Yes	No
17	Askari M	2013	India	Blood	–	Gene-specific methylation	Yes	Yes
18	Severi G	2014	Australia	Blood	–	Global DNA methylation	Yes	Yes
19	Yang RX	2014	Germany	Blood	–	Gene-specific methylation	Yes	Yes
20	Kuchiba A	2014	Japan	Blood	–	Global DNA methylation	Yes	Yes
21	Gupta S	2014	Poland	Blood	–	Gene-specific methylation	Yes	Yes
22	DeRoo LA	2014	USA	Blood	–	Global DNA methylation	No	Yes
23	van Veldhoven K	2015	Italy	Blood	–	Global DNA methylation	Yes	Yes
24	Cho YH	2015	USA	Blood	–	Gene-specific methylation	Yes	Yes
25	Yari K	2015	Iran	Blood	–	Gene-specific methylation	Yes	No
26	Harrison K	2015	Europe	Blood	–	Gene-specific methylation	Yes	Yes
27	Zmetakova I	2013	Slovakia	Blood and plasma	1000g for 10 min + 1000g for 10 min	Gene-specific methylation	Yes	No
28	Enders KN	2014	China	Blood and plasma	na	Gene-specific methylation	Yes	No
29	Hoque MO	2006	Senegal	Plasma	2200 rpm for 10–15 min	Gene-specific methylation	Yes	No
30	Papadopoulou E	2006	Greece	Plasma	2000 rpm for 10 min + 2000 rpm for 10 min	Gene-specific methylation	Yes	No
31	Yazici H	2009	USA	Plasma	na	Gene-specific methylation	Yes	No
32	Radpour R	2011	Switzerland	Plasma	16,006g for 10 min + full speed 10 min	Gene-specific methylation	Yes	No
33	Enders KO Ng	2011	China	Plasma	1600g for 10 min + 16,000g for 10 min	Gene-specific methylation	Yes	No
34	Chimonidou M	2013	Greece	Plasma	2000g for 10 min	Gene-specific methylation	Yes	No
35	Dulaimi E	2004	Pennsylvania	Serum	na	Gene-specific methylation	Yes	No
36	Martinez-Galan J	2008	Spain	Serum	2000g for 10 min	Gene-specific methylation	Yes	No
37	Van der Auwera I	2009	Belgium	Serum	2000g for 10 min	Gene-specific methylation	Yes	No
38	Chen Z	2009	China	Serum	1000g for 10 min	Gene-specific methylation	Yes	No
39	Zurita M	2010	Spain	Serum	2000g for 10 min	Gene-specific methylation	Yes	No
40	Ahmed IA	2010	Germany	Serum	2000g for 10 min	Gene-specific methylation	Yes	No
41	Brooks JD	2010	USA	Serum	na	Gene-specific methylation	Yes	No
42	Kim JH	2010	Korea	Serum	na	Gene-specific methylation	Yes	No
43	Kloten V	2013	Germany	Serum	2000g for 10 min	Gene-specific methylation	Yes	No
44	Swellam M	2015	Egypt	Serum	1600g for 15 min	Gene-specific methylation	Yes	No
45	Liu LM	2015	China	Serum	na	Gene-specific methylation	Yes	No

na not available

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ISSN: 1868-7083

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