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Table 1 Characteristics summary of the 45 eligible studies

From: Blood-based DNA methylation as biomarker for breast cancer: a systematic review

Number First author Year Country DNA source Sample treatment Measurement Methylation levels available Odds ratio estimation available
1 Widschwendter M 2008 Germany Blood Gene-specific methylation Yes Yes
2 Snell C 2008 Australia Blood Gene-specific methylation Yes No
3 Ito Y 2008 UK Blood Gene-specific methylation Yes Yes
4 Flanagan. JM 2009 UK Blood Gene-specific methylation Yes Yes
5 Choi JY 2009 USA Blood Global DNA methylation Yes Yes
6 Cho YH 2010 Turkey Blood Both global DNA methylation and gene-specific methylation Yes No
7 Hoffman AE 2010 Connecticut Blood Gene-specific methylation No Yes
8 Wong EM 2011 Australia Blood Gene-specific methylation Yes Yes
9 Iwamoto T 2011 Japan Blood Gene-specific methylation Yes Yes
10 Brennan K 2012 Australia, New Zealand, UK, and Europe Blood Both global DNA methylation and gene-specific methylation Yes Yes
11 Xu X 2012 USA Blood Global DNA methylation Yes Yes
12 Bosviel R 2012 France Blood Gene-specific methylation Yes No
13 Wu HC 2012 USA Blood Global DNA methylation Yes Yes
14 Delgado-Cruzata L 2012 USA Blood Global DNA methylation Yes Yes
15 Kitkumthorn N 2012 Thailand Blood Global DNA methylation Yes No
16 Hajikhan Mirzaei M 2012 Iran Blood Gene-specific methylation Yes No
17 Askari M 2013 India Blood Gene-specific methylation Yes Yes
18 Severi G 2014 Australia Blood Global DNA methylation Yes Yes
19 Yang RX 2014 Germany Blood Gene-specific methylation Yes Yes
20 Kuchiba A 2014 Japan Blood Global DNA methylation Yes Yes
21 Gupta S 2014 Poland Blood Gene-specific methylation Yes Yes
22 DeRoo LA 2014 USA Blood Global DNA methylation No Yes
23 van Veldhoven K 2015 Italy Blood Global DNA methylation Yes Yes
24 Cho YH 2015 USA Blood Gene-specific methylation Yes Yes
25 Yari K 2015 Iran Blood Gene-specific methylation Yes No
26 Harrison K 2015 Europe Blood Gene-specific methylation Yes Yes
27 Zmetakova I 2013 Slovakia Blood and plasma 1000g for 10 min + 1000g for 10 min Gene-specific methylation Yes No
28 Enders KN 2014 China Blood and plasma na Gene-specific methylation Yes No
29 Hoque MO 2006 Senegal Plasma 2200 rpm for 10–15 min Gene-specific methylation Yes No
30 Papadopoulou E 2006 Greece Plasma 2000 rpm for 10 min + 2000 rpm for 10 min Gene-specific methylation Yes No
31 Yazici H 2009 USA Plasma na Gene-specific methylation Yes No
32 Radpour R 2011 Switzerland Plasma 16,006g for 10 min + full speed 10 min Gene-specific methylation Yes No
33 Enders KO Ng 2011 China Plasma 1600g for 10 min + 16,000g for 10 min Gene-specific methylation Yes No
34 Chimonidou M 2013 Greece Plasma 2000g for 10 min Gene-specific methylation Yes No
35 Dulaimi E 2004 Pennsylvania Serum na Gene-specific methylation Yes No
36 Martinez-Galan J 2008 Spain Serum 2000g for 10 min Gene-specific methylation Yes No
37 Van der Auwera I 2009 Belgium Serum 2000g for 10 min Gene-specific methylation Yes No
38 Chen Z 2009 China Serum 1000g for 10 min Gene-specific methylation Yes No
39 Zurita M 2010 Spain Serum 2000g for 10 min Gene-specific methylation Yes No
40 Ahmed IA 2010 Germany Serum 2000g for 10 min Gene-specific methylation Yes No
41 Brooks JD 2010 USA Serum na Gene-specific methylation Yes No
42 Kim JH 2010 Korea Serum na Gene-specific methylation Yes No
43 Kloten V 2013 Germany Serum 2000g for 10 min Gene-specific methylation Yes No
44 Swellam M 2015 Egypt Serum 1600g for 15 min Gene-specific methylation Yes No
45 Liu LM 2015 China Serum na Gene-specific methylation Yes No
  1. na not available