Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial

Clinical Epigenetics

Table 2 LINE1 hypomethylation at birth and at 5 years for the DHA and control group

Subgroup	DHA group mean (SD)	Control group mean (SD)	Treatment effect DHA-control adjusted^a (95% CI)	P value, adjusted^a
Birth	1.47 (0.57)^b	1.43 (0.45)	0.04 (−0.02, 0.10)	0.211
5 years	0.99 (0.15)	0.99 (0.16)	0.00 (−0.02, 0.03)	0.706
Birth, female	1.56 (0.64)	1.50 (0.48)	0.06 (−0.04, 0.15)	0.229
Birth, male	1.39 (0.49)	1.36 (0.42)	0.03 (−0.06, 0.11)	0.583
5 years, female	1.04 (0.16)	1.03 (0.17)	0.01 (−0.03, 0.04)	0.655
5 years, male	0.95 (0.13)	0.95 (0.15)	0.00 (−0.03, 0.03)	0.837

All children who had any global DNA methylation data were used for this analysis; 522 children had data at birth and 5 years, 469 had data at birth only, 141 had data at 5 years only
^aAdjustment was made for centre, parity and gender
^bLINE1 methylation values are expressed as relative hypomethylation values compared to a reference sample

ISSN: 1868-7083