Table 2 Univariate Cox proportional hazard analysis of BCR-free survival in the training and validation cohort including PCa patients treated by radical prostatectomy

Age

411

1.02 (0.98–1.06)

0.39

259

1.01 (0.96–1.06)

0.70

Tumor stage (pT3 and pT4 vs. pT2 and pT1)

346

4.25 (2.37–7.61)

<0.001

260

2.07 (1.30–3.30)

0.001

ISUP Gleason grading group

411

1.69 (1.34–2.13)

<0.001

252

1.99 (1.63–2.42)

<0.001

Surgical margin (R1 vs. R0)

389

1.49 (0.87–2.56)

0.15

258

1.00 (0.98–1.02)

0.84

Nodal status (pN1 vs. pN0)

357

1.84 (1.00–3.36)

0.048

259

1.09 (0.50–2.41)

0.82

Preoperative PSA level

409

1.04 (1.02–1.05)

<0.001

250

1.01 (1.00–1.02)

0.11

AR activity score (positive vs. negative)

271

0.74 (0.32–1.71)

0.49

NA

NA

NA

AR protein expression (AR high vs. AR low)

NA

NA

NA

143

0.82 (0.40–1.70)

0.60

ERG^a (ERG-fusion positive vs. ERG-fusion negative)

271

0.80 (0.40–1.57)

0.51

182

0.78 (0.40–1.51)

0.46

mPITX3 (optimized cutoff, mPITX3 _high vs. mPITX3 _low)

411

1.83 (1.07–3.11)

0.027

250

2.56 (1.44–4.54)

0.001