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Table 6 Look-up in the Korean COPD cohort of CpGs reported at least two epigenome-wide association studies (70 CpGs at FDRg < 0.05, ordered by chromosomal location)

From: DNA methylation and smoking in Korean adults: epigenome-wide association study

Chra Gene Distance to geneb Probe Coefc P d Referencese
1 GNG12   cg25189904f −0.134 1.4E−06 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Tsaprouni et al. 2014[18]; Zhu et al. 2016 [26].
  cg26764244 −0.055 0.010 Guida et al. 2015 [12]; Harlid et al. 2014[17].
GFI1   cg12876356f −0.049 8.9E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg18316974 −0.014 0.006 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22].
  cg09935388 −0.106 8.1E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
AVPR1B   cg08709672f −0.058 1.1E−06 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg20295214 −0.068 3.5E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22].
PSEN2 −55213 cg03547355 −0.034 0.016 Guida et al. 2015 [12]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22].
2 LINC00299 195809 cg23079012f −0.023 3.8E−04 Besingi and Johansson 2014 [14]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
NFE2L2   cg26271591f −0.061 8.3E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22].
GPR55   cg19827923 −0.022 0.012 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
ALPP   cg23667432 −0.027 0.013 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22].
ECEL1P2 −90 cg27241845 −0.081 4.1E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Tsaprouni et al. 2014[18].
ALPPL2 11777 cg03329539f −0.064 3.9E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
12850 cg05951221f −0.088 8.4E−09 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Harlid et al. 2014[17]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Shenker et al. 2013[19]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
13382 cg01940273 −0.090 1.4E−06 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Shenker et al. 2013[19]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
13737 cg13193840f −0.027 1.1E−04 Guida et al. 2015 [12]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
SNED1   cg26718213 0.091 0.005 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14].
3 GPX1   cg18642234 −0.042 0.005 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
GPR15   cg19859270 −0.027 1.0E−07 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Harlid et al. 2014[17]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Sun et al. 2013[20]; Zeilinger et al. 2013 [22]; Wan et al. 2012[24]; Breitling et al. 2011[25]; Zaghlool et al. 2015[13]; Zhu et al. 2016 [26].
CPOX   cg02657160 −0.030 1.8E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Harlid et al. 2014[17]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22].
5 AHRR   cg11554391 −0.043 2.5E−04 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg12806681f −0.015 0.009 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg23916896f −0.063 0.006 Guida et al. 2015 [12]; Dogan et al. 2014[15]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg01899089f −0.054 0.003 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Zeilinger et al. 2013[22].
  cg05575921f −0.203 6.5E−13 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Harlid et al. 2014[17]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Shenker et al. 2013[19]; Zeilinger et al. 2013 [22]; Zaghlool et al. 2015[13]; Philibert et al. 2012[23]; Philibert et al. 2013[21]; Zhu et al. 2016 [26].
  cg14817490 −0.078 4.7E−06 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zaghlool et al. 2015[13]; Zhu et al. 2016 [26].
  cg17287155 −0.023 1.8E−04 Guida et al. 2015 [12]; Dogan et al. 2014[15]; Zhu et al. 2016 [26].
  cg04551776 −0.038 1.3E−04 Guida et al. 2015 [12]; Elliott et al. 2014 [16]; Zhu et al. 2016 [26].
  cg25648203 −0.079 6.2E−07 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Tsaprouni et al. 2014[18]; Zhu et al. 2016 [26].
  cg24090911 −0.039 0.009 Guida et al. 2015 [12]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
6 IER3 9104 cg06126421 −0.101 2.6E−04 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Shenker et al. 2013[19]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
9132 cg14753356f −0.062 1.7E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
9227 cg24859433 −0.037 0.003 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
9233 cg15342087 −0.030 0.009 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Tsaprouni et al. 2014[18]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
7 GNA12   cg18446336 −0.074 0.011 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
MYO1G   cg19089201 0.056 3.5E−05 Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg22132788 0.092 2.7E−06 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Philibert et al. 2012[23]; Philibert et al. 2013[21]; Zhu et al. 2016 [26].
  cg04180046 0.103 2.3E−05 Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg12803068 0.156 4.8E−06 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Philibert et al. 2012[23]; Philibert et al. 2013[21]; Zhu et al. 2016 [26].
CNTNAP2   cg21322436 −0.026 0.016 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg25949550 −0.026 5.2E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
8 MYST3   cg14316231 −0.029 0.007 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
9 SLC44A1 −1580 cg01692968f −0.038 0.004 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
10 ZMIZ1   cg03450842f −0.041 0.004 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14].
11 KCNQ1OT1   cg01744331 −0.030 8.4E−04 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22].
  cg07123182f −0.031 1.1E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg16556677f −0.051 6.7E−04 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  cg26963277f −0.043 6.2E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
LRP5   cg21611682 −0.045 0.005 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Tsaprouni et al. 2014[18]; Zhu et al. 2016 [26].
  cg10420527 −0.031 0.013 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
  cg14624207f −0.040 0.002 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
ARRB1   cg01901332 −0.057 0.008 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22].
PRSS23   cg23771366 −0.062 0.002 Guida et al. 2015 [12]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
12 ETV6   cg07986378f −0.069 3.6E−04 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zhu et al. 2016 [26].
14 C14orf43   cg01731783 −0.025 0.009 Guida et al. 2015 [12]; Dogan et al. 2014[15]; Elliott et al. 2014 [16]; Zeilinger et al. 2013 [22].
ITPK1   cg05284742 −0.055 2.5E−05 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
15 SEMA7A   cg00310412 −0.036 0.008 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22].
ANPEP   cg23161492 −0.055 0.001 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
16 XYLT1   cg16794579f −0.039 0.004 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14].
FBRS −4029 cg07069636 −0.023 0.006 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
17 LOC100130933   cg07251887f −0.070 2.4E−04 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22].
19 CIRBP −1591 cg00073090 −0.031 0.002 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
MOBKL2A   cg15187398 −0.048 0.013 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
MIR23A 3767 cg05339037 −0.025 0.008 Guida et al. 2015 [12]; Zhu et al. 2016 [26].
F2RL3   cg03636183f −0.128 2.0E−08 Allione et al. 2015 [11]; Guida et al. 2015 [12]; Besingi and Johansson 2014 [14]; Dogan et al. 2014[15]; Harlid et al. 2014[17]; Elliott et al. 2014 [16]; Tsaprouni et al. 2014[18]; Shenker et al. 2013[19]; Sun et al. 2013[20]; Zeilinger et al. 2013 [22]; Wan et al. 2012[24]; Breitling et al. 2011[25]; Zaghlool et al. 2015[13]; Zhu et al. 2016 [26].
PPP1R15A   cg03707168 −0.034 0.009 Guida et al. 2015 [12]; Besingi and Johansson 2014 [14].
20 ATP9A   cg07339236 −0.039 1.0E−04 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
21 NCRNA00114   cg06595162f −0.034 0.005 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22].
22 NCF4   cg02532700 −0.049 0.003 Guida et al. 2015 [12]; Zeilinger et al. 2013 [22]; Zhu et al. 2016 [26].
  1. aChromosome
  2. bDistance to transcription start site of the mapped gene (basepair, National Center for Biotechnology Information human reference genome assembly Build 37.3)
  3. cRegression coefficient from statistical model
  4. dStatistical significance from statistical model
  5. eArticles reporting CpGs as smoking-associated differential methylation sites at genome-wide level
  6. fProbe differentially methylated in both current and former smokers compared to never smokers in our epigenome-wide association study
  7. gCorrection for 18 tests at the look-up