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Table 4 CpGs differentially methylated in relation to smoking status also related to quantitative measures of smoking (p correlation <0.05, ordered by chromosomal location)

From: DNA methylation and smoking in Korean adults: epigenome-wide association study

Chra

Gene

Distance to geneb

Probe

Epigenome-wide association study

ρd

Pρ

Coefc

p

Urine cotinine in current smokers (N = 31)

 1

GNG12

 

cg25189904e,f

−0.134

1.4E−06

−0.40

0.027

 3

GPR15

 

cg19859270e,f

−0.027

1.0E−07

−0.56

0.001

 4

MTNR1A

 

cg22261866

−0.063

1.6E−06

0.37

0.041

 5

AHRR

 

cg05575921e,f

−0.203

6.5E−13

−0.43

0.016

 15

FAM82A2

 

cg19440278

0.007

7.0E−06

−0.43

0.016

 19

F2RL3

 

cg03636183e,f

−0.128

2.0E−08

−0.56

0.001

Pack-year in current smokers (N = 31)

 1

NT5C1A

 

cg00990022

−0.04

5.5E−06

0.39

0.036

 6

ZBTB9

 

cg03945003

−0.023

3.9E−06

0.40

0.031

 10

JAKMIP3

 

cg19134728e

−0.023

1.2E−05

0.37

0.045

 11

HPX

 

cg25426350

−0.03

2.5E−06

0.44

0.016

 11

CCND1

 

cg09520904

−0.036

7.5E−07

−0.44

0.015

 21

RNF160

 

cg13662262

−0.01

9.2E−06

0.44

0.015

Time since quit smoking in former smokers (N = 30)

 1

IFI16

−9970

cg19707735

−0.035

1.0E−04

0.47

0.009

 2

CLASP1

 

cg22346073

−0.052

8.0E−07

0.43

0.017

 3

ARHGEF3

 

cg25799109e

−0.076

4.4E−05

−0.44

0.016

 3

KTELC1

 

cg16958524

−0.029

6.9E−06

0.39

0.033

 5

SPEF2

 

cg08534016

−0.050

0.001

0.42

0.021

 6

ACOT13

16438

cg09447457

−0.010

1.2E−05

0.39

0.034

 9

BSPRY

 

cg02003202

−0.049

9.5E−06

0.44

0.015

 15

FAM82A2

 

cg21580007

−0.049

9.0E−04

0.47

0.009

  1. Results for current and former smokers showed regression coefficients and p values from EWAS for current and former smokers, respectively
  2. aChromosome
  3. bDistance to transcription start site of the mapped gene (basepair, based on National Center for Biotechnology Information human reference genome assembly Build 37.3)
  4. cRegression coefficient from statistical model
  5. dSpearman correlation (rho) was used for urine cotinine and pack-years in current smokers and time since quit smoking in former smokers. The methylation values were adjusted for age, sex, body mass index, chronic obstructive pulmonary disease status, and estimated cell composition
  6. eProbe identified in previous epigenome-wide association studies (EWASs) of smoking
  7. fProbe identified in one previous EWAS of serum cotinine