Fig. 1

The activating histone modification H3K4me3 increases on pro-inflammatory cytokine promoters as development progresses over the third trimester. ChIP assays were performed to determine the H3K4me3 and H3K27me3 profiles throughout fetal development of the a IL1B promoter, b IL6 promoter, c IL12B promoter, and d TNF promoter. <30 n = 25, 30–36 n = 10, 37+ n = 10. *p < 0.05, **p < 0.01. Box represents 25th–75th percentile range, and whiskers represent minimum to maximum values