From: Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy
Patients | Analysis model | Variables | Recurrence | |||
---|---|---|---|---|---|---|
HR | (95Â % CI) | P value | ||||
All | ||||||
 | Univariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.78 | (1.48, 2.16) | 2.05E−09 | |
 | Multivariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.48 | (1.21, 1.81) | 1.38E−04 | |
 |  | Age (per 1-year increase) | 0.98 | (0.95, 1.01) | 0.21 | |
 |  | Gleason score |  |  |  | |
 |  |  | ≤6 | 1.00 |  |  |
 |  |  | 7(3 + 4) | 2.25 | (1.32, 3.48) | 2.89E−03 |
 |  |  | 7(4 + 3) | 5.04 | (2.64, 9.65) | 1.02E−06 |
 |  |  | 8–10 | 4.06 | (2.00, 8.26) | 1.08E−04 |
 |  | Pathological stagea |  |  |  | |
 |  |  | Local | 1.00 |  |  |
 |  |  | Regional | 2.04 | (1.33, 3.14) | 1.13E−03 |
 |  | Diagnostic PSA level (per 1-unit increase) | 1.00 | (1.00, 1.00) | 0.92 | |
Patients with Gleason 7 tumors | ||||||
 | Univariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.81 | (1.42, 2.31) | 1.38E−06 | |
 | Multivariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.59 | (1.24, 2.05) | 3.21E−04 | |
 |  | Age (per 1-year increase) | 0.99 | (0.95, 1.03) | 0.56 | |
 |  | Gleason score |  |  |  | |
 |  |  | 7(3 + 4) | 1.00 |  |  |
 |  |  | 7(4 + 3) | 2.08 | (1.18, 3.65) | 1.09E−02 |
 |  | Pathological stagea |  |  |  | |
 |  |  | Local | 1.00 |  |  |
 |  |  | Regional | 1.82 | (1.06, 3.11) | 2.94E−02 |
 |  | Diagnostic PSA level (per 1-unit increase) | 1.00 | (0.99, 1.01) | 0.82 | |
Patients with Gleason 7(3 + 4) tumors | ||||||
 | Univariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.83 | (1.36, 2.45) | 5.64E−05 | |
 | Multivariate |  |  |  |  | |
 |  | Signature (per 25 % increase) | 1.65 | (1.21, 2.25) | 1.54E−03 | |
 |  | Age (per 1-year increase) | 1.00 | (0.95, 1.05) | 0.86 | |
 |  | Pathological stagea |  |  |  | |
 |  |  | Local | 1.00 |  |  |
 |  |  | Regional | 1.83 | (0.97, 3.45) | 0.06 |
 |  | Diagnostic PSA level (per 1-unit increase) | 1.00 | (0.99, 1.01) | 0.80 |