Table 1 Details of SPMS and healthy control individuals
| Â | Next generation sequencing | Replication cohort | ||
|---|---|---|---|---|
SPMS | HC | SPMS | HC | |
Number | 12 | 12 | 12 | 10 |
Female | 9 | 9 | 8 | 5 |
Age in years (mean ± SD) | 60.2 ± 8.3 | 61.3 ± 9.5 | 61.4.0 ± 6.5 | 60.1 ± 5.9 |
EDSS (mean ± SD) | 6.9 ± 0.9 | NA | 5.9 ± 1.0 | NA |
Active SPMS | 3 | NA | 4 | NA |
Disease duration in years (mean ± SD) | 25.6 ± 11.1 | NA | 18.3 ± 6.5 | NA |
Progression duration (mean ± SD) | 10.8 ± 8.1 | NA | 8.9 ± 6.2 | NA |