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Table 1 Differentially expressed genes in patients with ANCA-associated vasculitis compared to healthy controls regulating histone post-translational modifications and DNA methylation

From: Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

Gene symbol Fragment name Entrez gene name ANCA/HC p ANCA/HC fold change
Histone H4K16, H4K5, H4K12 acetylation
MSL3 207551_s_at male-specific lethal 3 homolog 0.0002 1.65
MSL1 224765_at male-specific lethal 1 homolog <0.0001 1.60
KAT8 221820_s_at lysine acetyltransferase 8 0.0187 1.38
BRD4 226052_at bromodomain containing 4 0.0003 1.38
ING4 218234_a inhibitor of growth family, member 4 <0.0001 −2.05
Histone H3K4 methylation
MLL3 222415_at myeloid/lymphoid or mixed-lineage leukemia 3 <0.0001 1.53
MLL2 231974_at myeloid/lymphoid or mixed-lineage leukemia 2 0.0003 1.51
MLL4 203419_at myeloid/lymphoid or mixed-lineage leukemia 4 0.0107 1.26
RTF1 212302_at Rtf1, Paf1/RNA polymerase II complex component 0.0409 1.24
BCOR 223566_s_at BCL6 corepressor <0.0001 −1.74
KDM1A 212348_s_at lysine-specific demethylase 1A 0.0002 −1.57
C14orf169 219526_at lysine-specific demethylase NO66 0.0002 −1.34
Histone H3K14 acetylation
BRD4 226052_at bromodomain containing 4 0.0003 1.38
Histone H3K36 methylation
NSD1 225654_at nuclear receptor binding SET domain protein 1 0.0208 1.34
BCOR 223566_s_at BCL6 corepressor <0.0001 −1.74
C14orf169 219526_at lysine-specific demethylase NO66 0.0002 −1.34
Histone H3K9 methylation
EHMT1 222873_s_at euchromatic histone-lysine N-methyltransferase 1 0.0084 −1.41
EHMT2 202326_at euchromatic histone-lysine N-methyltransferase 2 0.0013 −1.44
ARID4B 212591_at AT rich interactive domain 4B (RBP1-like) <0.0001 −1.51
Histone H4K20 methylation
ARID4B 212591_a AT rich interactive domain 4B (RBP1-like) <0.0001 −1.51
DNA methylation
DNMT1 201697_s_at DNA (cytosine-5-)-methyltransferase 1 <0.0001 −2.03