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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction

Fig. 4

DNAm changes in IUGR twins in LEPR promoter. Methylation levels in IUGR twins (orange circles) and unaffected co-twins (blue crosses) are shown, arranged vertically for each CpG in the region spanning the promoter of one of the LEPR gene transcripts. The mean methylation levels are shown for the IUGR cohort (red line) and controls (blue line). The top three CpGs with methylation change above 10 % comprise the DMR (red box), which also corresponds to the wider gap between the red and blue lines

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