Fig. 6

Overview about the effect sizes, calculated as Cohen’s d, obtained when using the LINE-1 or the LUMA approach to the quantification of global DNA methylation. A total of n = 72 effect sizes was calculated from a comparison of every treatment with every other treatment to which the cell lines had been exposed (Table 2; DMSO and untreated conditions combined). The bar plot (left) shows the effect sizes that would be obtained when using either the Line-1 (green) or the LUMA (gold) method in pairs for each paired comparison between two treatments. The histogram (right) shows the high degree of superposition of the effect sizes that would be obtained when applying the two assays