DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Cao-Lei, Lei; Veru, Franz; Elgbeili, Guillaume; Szyf, Moshe; Laplante, David P.; King, Suzanne

doi:10.1186/s13148-016-0219-0

Table 2 Significant mediating effects of gene methylation on IFN-γ outcome

From: DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Gene	CpG site	DNA methylation				IFN-γ outcome							Mediation effect
		R ²	Storm32			R ²	DNA methylation			Storm32			Mediation effect
		R ²	Effect (a)	SE	p val.	R ²	Effect (b)	SE	p val.	Effect (c')	SE	p val.	Effect (ab*)	Boot SE	Boot LLCI	Boot ULCI	Standardized effect
DDR1	cg11975790	0.1813	0.0527	0.0201	0.0135	0.1749	−0.4065	0.1856	0.0364	0.0474	0.0230	0.0478	−0.0214	0.0116	−0.0537	−0.0045	−0.170991
FLT1	cg24850711	0.2527	0.0606	0.0187	0.0029	0.1142	−0.3210	0.2065	0.1306	0.0454	0.0249	0.0782	−0.0195	0.0129	−0.0540	−0.0010	−0.155283
IGF1R	cg13297560	0.1322	0.0388	0.0178	0.0375	0.1376	−0.3883	0.2139	0.0795	0.0410	0.0228	0.0822	−0.0151	0.0113	−0.0475	−0.0007	−0.120139
IL1R2	cg12910851	0.1628	0.0353	0.0144	0.0199	0.2001	−0.6216	0.2560	0.0214	0.0479	0.0224	0.0406	−0.0219	0.0151	−0.0659	−0.0031	−0.174821
LCK	cg17078393	0.2561	0.0659	0.0202	0.0027	0.1783	−0.4104	0.1846	0.0339	0.0530	0.0241	0.0353	−0.0271	0.0139	−0.0640	−0.0055	−0.21591
	cg05350315	0.1949	0.0711	0.0260	0.0101	0.1651	−0.3033	0.1447	0.0447	0.0475	0.0233	0.0503	−0.0216	0.0145	−0.0629	−0.0019	−0.172012
	cg11683242	0.1681	0.0443	0.0177	0.0178	0.2545	−0.5858	0.2007	0.0066	0.0519	0.0217	0.0231	−0.0259	0.0126	−0.0599	−0.0073	−0.206796
	cg14781242	0.2081	0.0505	0.0177	0.0076	0.1625	−0.4395	0.2124	0.0472	0.0482	0.0235	0.0495	−0.0222	0.0109	−0.0519	−0.0063	−0.177247
LTA	cg16280132	0.3331	0.0652	0.0166	0.0004	0.1463	−0.4366	0.2291	0.0663	0.0544	0.0259	0.0440	−0.0285	0.0152	−0.0654	−0.0047	−0.227195
	cg09736959	0.2952	0.0758	0.0210	0.0011	0.1433	−0.3391	0.1809	0.0706	0.0517	0.0252	0.0494	−0.0257	0.0150	−0.0628	−0.0014	−0.20498
	cg24216966	0.2611	0.0886	0.0268	0.0024	0.1401	−0.2620	0.1423	0.0755	0.0492	0.0247	0.0555	−0.0232	0.0144	−0.0628	−0.0022	−0.185282
	cg01157951	0.2634	0.0663	0.0199	0.0023	0.1334	−0.3402	0.1922	0.0869	0.0485	0.0248	0.0600	−0.0225	0.0140	−0.0592	−0.0010	−0.179876
	cg21999229	0.2593	0.1120	0.0340	0.0025	0.1287	−0.1940	0.1129	0.0961	0.0477	0.0248	0.0643	−0.0217	0.0142	−0.0592	−0.0002	−0.17327
	cg14597739	0.2618	0.1198	0.0361	0.0023	0.1504	−0.2043	0.1049	0.0608	0.0504	0.0246	0.0487	−0.0245	0.0156	−0.0674	−0.0021	−0.195257
	cg16219283	0.2575	0.1038	0.0316	0.0026	0.1430	−0.2250	0.1202	0.0710	0.0493	0.0246	0.0540	−0.0234	0.0151	−0.0641	−0.0010	−0.186303
	cg13815684	0.2571	0.0877	0.0268	0.0026	0.1569	−0.2838	0.1410	0.0531	0.0509	0.0244	0.0456	−0.0249	0.0141	−0.0635	−0.0038	−0.198557
	cg10476003	0.2229	0.0794	0.0266	0.0055	0.1749	−0.3071	0.1402	0.0364	0.0504	0.0236	0.0410	−0.0244	0.0138	−0.0656	−0.0048	−0.194562
	cg09621572	0.2220	0.1022	0.0343	0.0056	0.1447	−0.2091	0.1107	0.0686	0.0473	0.0240	0.0578	−0.0214	0.0141	−0.0609	−0.0024	−0.170417
	cg17169196	0.2233	0.0894	0.0299	0.0055	0.1638	−0.2615	0.1255	0.0459	0.0493	0.0237	0.0464	−0.0234	0.0138	−0.0624	−0.0042	−0.186458
	cg02402436	0.2261	0.0932	0.0310	0.0052	0.1323	−0.2173	0.1236	0.0890	0.0462	0.0242	0.0661	−0.0203	0.0129	−0.0574	−0.0018	−0.161559
	cg14441276	0.2038	0.0741	0.0263	0.0084	0.1409	−0.2678	0.1448	0.0742	0.0458	0.0238	0.0634	−0.0199	0.0136	−0.0591	−0.0010	−0.158425
	cg11586857	0.1575	0.0561	0.0233	0.0222	0.1857	−0.3647	0.1590	0.0290	0.0464	0.0225	0.0477	−0.0205	0.0123	−0.0566	−0.0033	−0.163339
	cg14437551	0.1758	0.0986	0.0383	0.0151	0.1758	−0.2304	0.0961	0.0230	0.0487	0.0226	0.0393	−0.0227	0.0140	−0.0635	−0.0035	−0.181167
LTBR	cg23079808	0.1487	−0.0474	0.0204	0.0267	0.2281	0.4754	0.1772	0.0118	0.0485	0.0218	0.0337	−0.0225	0.0123	−0.0521	−0.0046	−0.179865
MAP3K14	cg16826777	0.1665	−0.0516	0.0207	0.0184	0.2136	0.4488	0.1759	0.0161	0.0491	0.0222	0.0349	−0.0231	0.0123	−0.0568	−0.0055	−0.184658
NFKBIA	cg00689225	0.2086	0.0668	0.0234	0.0075	0.2304	−0.4173	0.1544	0.0112	0.0538	0.0226	0.0236	−0.0279	0.0127	−0.0630	−0.0095	−0.222303
NFKBIA	cg16518861	0.1288	0.0439	0.0205	0.0403	0.2475	−0.4968	0.1740	0.0077	0.0478	0.0213	0.0322	−0.0218	0.0127	−0.0579	−0.0046	−0.173912
PIK3CD	cg01320698	0.3012	0.0487	0.0133	0.0009	0.2948	−0.8481	0.2591	0.0027	0.0673	0.0230	0.0065	−0.0413	0.0172	−0.0857	−0.0155	−0.329546
PIK3CD	cg07499142	0.1747	0.0599	0.0234	0.0155	0.1688	−0.3416	0.1603	0.0413	0.0464	0.0230	0.0522	−0.0205	0.0109	−0.0480	−0.0034	−0.163265
PIK3R2	cg11953794	0.2101	−0.0753	0.0262	0.0073	0.2804	0.4185	0.1330	0.0037	0.0575	0.0218	0.0133	−0.0315	0.0134	−0.0659	−0.0109	−0.251347
PIK3R2	cg04610450	0.1700	−0.0442	0.0176	0.0171	0.2369	0.5647	0.2045	0.0097	0.0510	0.0219	0.0272	−0.0250	0.0127	−0.0600	−0.0068	−0.199292
PRKCZ	cg02481000	0.1183	−0.0434	0.0213	0.0501	0.1988	0.4175	0.1728	0.0220	0.0441	0.0218	0.0523	−0.0181	0.0120	−0.0530	−0.0024	−0.14457
TGFBR2	cg04916416	0.1641	0.0412	0.0167	0.0193	0.1691	−0.4793	0.2246	0.0411	0.0457	0.0228	0.0543	−0.0197	0.0114	−0.0514	−0.0032	−0.157375
TLR6	cg14578677	0.1978	−0.0707	0.0256	0.0095	0.1637	0.3060	0.1470	0.0460	0.0476	0.0234	0.0506	−0.0216	0.0130	−0.0563	−0.0029	−0.172535
TNFAIP3	cg22014112	0.1467	0.0563	0.0244	0.0278	0.1868	−0.3499	0.1519	0.0284	0.0457	0.0223	0.0497	−0.0197	0.0131	−0.0576	−0.0024	−0.157265
TNFRSF1B	cg05599723	0.1221	−0.0465	0.0224	0.0462	0.1850	0.3790	0.1657	0.0294	0.0436	0.0221	0.0573	−0.0176	0.0111	−0.0496	−0.0024	−0.140605
	cg15526535	0.1349	0.0389	0.0177	0.0355	0.1947	−0.4959	0.2086	0.0240	0.0453	0.0221	0.0493	−0.0193	0.0113	−0.0496	−0.0038	−0.153835
	cg22677556	0.2258	0.0679	0.0226	0.0052	0.1711	−0.3567	0.1656	0.0394	0.0502	0.0237	0.0424	−0.0242	0.0107	−0.0539	−0.0084	−0.193363
TRAF5	cg10721755	0.1654	−0.0516	0.0208	0.0188	0.2716	0.5175	0.1686	0.0045	0.0527	0.0214	0.0198	−0.0267	0.0140	−0.0644	−0.0070	−0.212858
ZAP70	cg08859278	0.1844	0.0475	0.0179	0.0126	0.2533	−0.5756	0.1979	0.0068	0.0533	0.0219	0.0211	−0.0273	0.0135	−0.0627	−0.0073	−0.2181

Mediation effects that survived Bonferroni correction are presented in italics
BCL10 B cell CLL/lymphoma 10, DDR1 discoidin domain receptor tyrosine kinase 1, FLT1 Fms-related tyrosine kinase 1, IGF1R insulin-like growth factor 1 receptor, IL1R2 interleukin 1 receptor, type II, LCK lymphocyte-specific protein tyrosine kinase, LTA lymphotoxin alpha, LTBR lymphotoxin beta receptor (TNFR superfamily, member 3), MAP3K14 mitogen-activated protein kinase kinase kinase 14, MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4, NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B cell inhibitor, alpha, PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta, PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta), PRKCZ protein kinase C, zeta, TGFBR2 transforming growth factor, beta receptor II, TLR6 Toll-like receptor 6, TNFAIP3 tumor necrosis factor, alpha-induced protein 3, TNFRSF1B tumor necrosis factor receptor superfamily, member 1B, TRAF5 TNF receptor-associated factor 5, ZAP70 zeta-chain (TCR)-associated protein kinase 70 kDa, SE standard error, LLCI lower limit confidence interval, ULCI upper limit confidence interval

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com

Clinical Epigenetics

Contact us