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Table 6 Univariate and multivariate Cox regression analyses for recurrence-free survival in stage III colon cancers (n = 268)

From: Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients

Parameters Univariate analysis Multivariate analysis
HR 95 % C.I. P a HR 95 % C.I. P a
Gender (male vs. female) 1.96 0.881–4.367 0.099    
Age (≥60 years vs. <60 years) 1.54 0.775–3.161 0.234    
BMI (overweight vs. normal) 2.23 0.966–5.164 0.060    
Tumor location (distal vs. proximal) 2.32 0.955–5.637 0.063    
Pathology (mucinous vs. non-mucinous) 1.71 0.409–7.166 0.462    
Differentiation (high grade vs. low grade) 1.41 0.428–4.619 0.575    
T stage (T4 vs. T1, 2, 3) 2.97 1.284–6.865 0.011 2.50 1.065–5.854 0.035
N stage (N2 vs. N0, 1) 2.40 1.196–4.795 0.014 2.26 1.114–4.575 0.024
Microsatellite status (MSI-H vs. MSS + MSI-L) 1.06 0.254–4.451 0.933    
Performance status (PS ≥ 1 vs. PS 0) 1.63 0.782–3.394 0.192    
LINE-1 methylation (low vs. high) 3.36 1.287–8.781 0.013 3.50 1.338–9.126 0.011
  1. BMI body mass index, MSS microsatellite stable, MSI-L microsatellite instability-low, MSI-H microsatellite instability-high, PS performance status
  2. aCox proportional hazard regression model, adjusted for other selected covariates