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Table 4 Univariate and multivariate Cox regression analyses for recurrence-free survival in stage III or high-risk stage II CRCs (n = 336)

From: Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients

Parameters Univariate analysis Multivariate analysis
HR 95 % C.I. P HR 95 % C.I. P a
T stage (T4 vs. T1, 2, 3) 2.41 1.179–4.908 0.016 2.36 1.153–4.818 0.019
N stage (N 2 vs. N0, 1) 2.51 1.355–4.654 0.003 2.43 1.309–4.513 0.005
Performance status—LINE-1 methylation       
 PS(0)/LINE-1 (high) Ref.    Ref.   
 PS(0)/LINE-1 (low) 2.02 0.684–5.936 0.203 2.07 0.704–6.105 0.185
 PS(≥1)/LINE-1 (high) 1.25 0.360–4.337 0.343 1.20 0.344–4.152 0.778
 PS(≥1)/LINE-1 (low) 2.72 1.013–7.325 0.047 2.59 0.966–6.964 0.059
  1. BMI body mass index, ECOG Eastern Cooperative Oncology Group, MSS microsatellite stable, MSI-L microsatellite instability-low, MSI-H microsatellite instability-high, PS performance status
  2. aCox proportional hazard regression model, adjusted for other selected covariates