Table 4 Univariate and multivariate Cox regression analyses for recurrence-free survival in stage III or high-risk stage II CRCs (n = 336)

T stage (T4 vs. T1, 2, 3)

2.41

1.179–4.908

0.016

2.36

1.153–4.818

0.019

N stage (N 2 vs. N0, 1)

2.51

1.355–4.654

0.003

2.43

1.309–4.513

0.005

Performance status—LINE-1 methylation

 PS(0)/LINE-1 (high)

Ref.

Ref.

 PS(0)/LINE-1 (low)

2.02

0.684–5.936

0.203

2.07

0.704–6.105

0.185

 PS(≥1)/LINE-1 (high)

1.25

0.360–4.337

0.343

1.20

0.344–4.152

0.778

 PS(≥1)/LINE-1 (low)

2.72

1.013–7.325

0.047

2.59

0.966–6.964

0.059