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Table 1 Baseline characteristics of the epidemiological and clinical variables of the study population

From: Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients

Parameters ECOG performance status
Case N (%) 0 N (%) ≥1 N (%) P valuea P valueb OR
Gender   
 Female 125 (37.2) 64 (38.6) 61 (35.9)    
 Male 211 (62.8) 102 (61.4) 109 (64.1) 0.612 0.699 1.10
Age (median)   
 <60 years 165 (49.1) 90 (54.2) 75 (44.1)    
 ≥60 years 171 (50.9) 76 (45.8) 95 (55.9) 0.064 0.126 1.37
BMI   
 Normal 135 (40.2) 74 (44.6) 61 (35.9)    
 Overweight 201 (59.8) 92 (55.4) 109 (64.1) 0.104 0.234 1.33
Tumor location   
 Proximal 105 (31.3) 54 (32.5) 51 (30.0)    
 Distal 231 (68.7) 112 (67.5) 119 (70.0) 0.617 0.885 1.11
Pathology   
 Non-mucinous carcinoma 321 (95.5) 160 (96.4) 161 (94.7)    
 Mucinous adenocarcinoma 15 (4.5) 6 (3.6) 9 (5.3) 0.599c 0.965 0.82
Differentiation   
 Low grade 311 (92.6) 156 (94.0) 155 (91.2)    
 High grade 25 (7.4) 10 (6.0) 15 (8.8) 0.328 0.185 2.51
T stage   
 T1, 2, 3 293 (87.2) 147 (88.6) 146 (85.9) 0.464 0.568 1.08
 T4 43 (12.8) 19 (11.4) 24 (14.1)    
N stage   
 N 0, 1 252 (75.0) 133 (80.2) 119 (70.0) 0.032 0.088 1.67
 N 2 84 (25.0) 33 (19.9) 51 (30.0)    
Microsatellite status   
 MSS + MSI-L 313 (93.1) 149 (89.8) 164 (96.5) 0.035 0.024 0.30
 MSI-H 21 (6.3) 15 (9.0) 6 (3.5)    
 Missing 2 (0.6) 2 (1.2) 0    
KRAS       
 Wild type 230 (68.5) 122 (73.5) 108 (63.5) 0.342 0.367 1.38
 Mutant type 81 (24.1) 38 (22.9) 43 (25.3)    
 Missing 25 (7.4) 6 (3.6) 19 (11.2)    
BRAF       
 Wild type 316 (94.0) 159 (95.8) 157 (92.4 %) 0.333 0.502 0.56
 Mutant type 9 (2.7) 6 (3.6) 3 (1.8)    
 Missing 11 (3.3) 1 (0.6) 10 (5.9)    
TNR (median)   
 <0.69 173 (51.5) 71 (42.8) 102 (60.0) 0.002 0.001 0.04
 ≥0.69 163 (48.5) 95 (57.2) 68 (40.0)    
  1. BMI body mass index, ECOG Eastern Cooperative Oncology Group, MSS microsatellite stable, MSI-L microsatellite instability-low, MSI-H microsatellite instability-high, TNR tumor to normal ratio
  2. aChi-square test
  3. bUnconditional logistic regression, adjusted for other selected covariates
  4. cFisher’s exact test