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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Fig. 1

Tumor cell line derived from primary mammary cell mimics clinical breast cancer tissues. a HMC-p6, HMC-LTR, TCGA 100-paired breast cancer, and normal tissues are clustered by the expression of the overlapped differentially expressed genes (DEGs). Hierarchical cluster heatmap is shown using Ward method. b, c Biological process (BP) enrichment analysis of TCGA and LTR total DEGs. GO analysis was performed with DAVID, and items were ordered by P value. d BP enrichment analysis of LT/p6 (left) and LT/p6 up-regulated (right) DEGs. e A sketch map of biological processes changed during each step of cell transformation according to their gene expression profiles

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Clinical Epigenetics

ISSN: 1868-7083

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