Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

Clinical Epigenetics

Table 6 Survival of colorectal cancer patients treated with surgery and chemotherapy compared with patients treated with surgery alone

CIMP group	CIMP definition	Study	Group size	Analysis	Survival	HR (95 % CI)	p value
CIMP+	D 14	Li (2014) [34]	37	M	OS	0.71 (0.20–2.54)	0.60
	D 2	Shiovitz (2014)^a [35]	145	M	OS	0.62 (0.37–1.05)^b	0.07
	D 8	Jover (2011) [5]	89	M	DFS	0.80 (0.30–2.00)	0.60
CIMP−	D 14	Li (2014) [34]	245	M	OS	1.09 (0.65–1.82)	0.75
	D 2	Shiovitz (2014)^a [35]	470	M	OS	1.38 (1.00–1.89)	0.05
	D 5	Rijinsoever (2003) [41]	139	M	DSS	0.96 (0.62–1.49)	0.86
	D 8	Jover (2011) [5]	213	M	DFS	0.40 (0.20–0.60)	<0.01

CI confidence interval, HR hazard ratio
^aResults comparing patients treated with surgery + LV + FU + IFL with patients treated with surgery + LV + FU
^bHR of surgery + chemotherapy compared with surgery alone in CIMP+ group was not reported directly in the study and was calculated according to 95 % CI

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