Skip to main content

Advertisement

Table 6 Survival of colorectal cancer patients treated with surgery and chemotherapy compared with patients treated with surgery alone

From: Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

CIMP group CIMP definition Study Group size Analysis Survival HR (95 % CI) p value
CIMP+ D 14 Li (2014) [34] 37 M OS 0.71 (0.20–2.54) 0.60
  D 2 Shiovitz (2014)a [35] 145 M OS 0.62 (0.37–1.05)b 0.07
  D 8 Jover (2011) [5] 89 M DFS 0.80 (0.30–2.00) 0.60
CIMP− D 14 Li (2014) [34] 245 M OS 1.09 (0.65–1.82) 0.75
  D 2 Shiovitz (2014)a [35] 470 M OS 1.38 (1.00–1.89) 0.05
  D 5 Rijinsoever (2003) [41] 139 M DSS 0.96 (0.62–1.49) 0.86
  D 8 Jover (2011) [5] 213 M DFS 0.40 (0.20–0.60) <0.01
  1. CI confidence interval, HR hazard ratio
  2. aResults comparing patients treated with surgery + LV + FU + IFL with patients treated with surgery + LV + FU
  3. bHR of surgery + chemotherapy compared with surgery alone in CIMP+ group was not reported directly in the study and was calculated according to 95 % CI