X chromosome-wide analysis identifies DNA methylation sites influenced by cigarette smoking

Clinical Epigenetics

Table 2 Smoking-related DNAm sites on X chromosome in males

CpG sites	Genes	Datasets	β-value				M-value
CpG sites	Genes	Datasets	Beta	SE	T-stat	p-value	Beta	SE	T-stat	p-value
cg07764473	BCOR	Twins I	0.058	0.009	6.02	1.21 × 10⁻⁷	0.35	0.058	6.05	1.05 × 10⁻⁷
		Twins II	0.030	0.013	2.42	0.02	0.18	0.078	2.25	0.03
		GSE50660	0.028	0.016	1.78	0.07	0.16	0.091	1.80	0.07
		GSE42861	0.037	0.014	2.57	0.01	0.22	0.084	2.58	0.01
		Meta	0.043	0.006	6.82	9.17 × 10⁻¹²	0.25	0.037	6.83	8.57 × 10⁻¹²
cg21380860	TSC22D3	Twins I	−0.020	0.004	−5.14	3.30 × 10⁻⁶	−0.19	0.037	−5.04	4.71 × 10⁻⁶
		Twins II	−0.014	0.007	−2.14	0.04	−0.13	0.059	−2.13	0.04
		GSE50660	−0.015	0.008	−1.91	0.06	−0.11	0.061	−1.86	0.06
		GSE42861	−0.014	0.008	−1.62	0.11	−0.10	0.065	−1.55	0.12
		Meta	−0.017	0.003	−6.03	1.61 × 10⁻⁹	−0.15	0.026	−5.81	6.25 × 10⁻⁹

ISSN: 1868-7083