DNA methylation and hormone receptor status in breast cancer

Clinical Epigenetics

Table 2 Number of associations between DNA methylation and hormone receptor-positive breast cancer in the BCCC dataset

Analysis	Number of coefficients^a	No. of positive associations	No. of inverse associations	% positive^b	95 % CI	Ratio^c	95 % CI
Training dataset (N = 807 genes)
All associations	806	548	258	68	(66, 72)	2.2	(1.9, 2.6)
Associations with P value ≤0.20	180	146	34	81	(75, 86)	4.3	(3.0, 6.4)
Associations with P value ≤0.05	46	38	8	83	(70, 93)	4.8	(2.4, 12.7)

^aNumber of logistic regression coefficients involved in each analysis
^bPercentage of coefficients that represent a positive association between methylation and hormone receptor-positive breast cancer.
^cRatio of the number of positive divided by the number of negative associations

ISSN: 1868-7083