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Fig. 4 | Clinical Epigenetics

Fig. 4

From: The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation

Fig. 4

Methylation of the NR3C1 promoters 1F and 1H. a Frequency distribution of the sum of the methylation throughout promoter 1F. Female donors, open circles; male donors, open triangles. b Frequency distribution of the sum of the methylation throughout promoter 1H. Female donors, open circles; male donors, open triangles. c Pearson’s correlation coefficients were calculated for all CpG pairs and subsequently plotted against the physical distance measured in nucleotides, demonstrating that the closer two CpG nucleotides are, the stronger their correlation in methylation levels. Each data point represents Pearson’s correlation coefficient for one pair of CpGs from all donors. d Pearson’s correlation in methylation levels between sum methylation levels in promoter 1F and 1H. Each data point represents one participant

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