Epigenetic associations of type 2 diabetes and BMI in an Arab population

Al Muftah, Wadha A.; Al-Shafai, Mashael; Zaghlool, Shaza B.; Visconti, Alessia; Tsai, Pei-Chien; Kumar, Pankaj; Spector, Tim; Bell, Jordana; Falchi, Mario; Suhre, Karsten

doi:10.1186/s13148-016-0177-6

Clinical Epigenetics

Table 2 Replication of BMI-DNA methylation associations in the Qatari family study. The betas represent the slope of the regression model indicating the rate of change in the dependent variable (trait) as independent variable (methylation beta value) changes. Coordinates are in hg19

From: Epigenetic associations of type 2 diabetes and BMI in an Arab population

Probe	Chr	Position	Gene symbol	Beta	SE	p value	Reference
cg18181703	17	76354621	SOCS3	−10.78	2.34	3.99 × 10⁻⁶	[12]
cg11024682	17	17730094	SREBF1	14.56	3.56	4.33 × 10⁻⁵	[15]
cg07573872	19	1126342	SBNO2	−9.96	2.48	5.87 × 10⁻⁵	[15]
cg00574958	11	68607622	CPT1A	−21.04	5.33	7.99 × 10⁻⁵	[15]
cg07136133	11	36422377	PRR5L	−10.43	2.79	1.85 × 10⁻⁴	[15]
cg03078551	17	41656298	NA	−19.23	5.85	1.00 × 10⁻³	[15]
cg13123009	6	31681882	LY6G6E	12.41	3.80	1.10 × 10⁻³	[15]
cg09349128	22	50327986	NA	−9.60	3.04	1.60 × 10⁻³	[15]
cg08972190	7	2138995	MAD1L1	11.11	3.54	1.70 × 10⁻³	[15]
cg06192883	15	52554171	MYO5C	6.68	2.27	3.20 × 10⁻³	[15]
cg06500161	21	43656587	ABCG1	11.90	4.17	4.30 × 10⁻³	[12]
cg27243685	21	43642366	ABCG1	11.01	4.11	7.30 × 10⁻³	[15]
cg06946797	16	11422409	NA	−6.24	2.36	8.10 × 10⁻³	[15]
cg12992827	3	101901234	NA	−5.60	2.14	8.90 × 10⁻³	[15]
cg23998749	1	154968781	NA	7.47	2.87	9.30 × 10⁻³	[15]
cg26354221	22	24822802	ADORA2A	12.11	4.77	0.011	[15]
cg11592786	15	89533581	NA	−28.45	12.46	0.022	[15]
cg26403843	5	158634085	RNF145	3.63	1.61	0.024	[12]
cg26033520	10	74004071	NA	4.92	2.20	0.025	[15]
cg01844514	7	149557121	ZNF862	6.55	3.48	0.060	[15]
cg14017402	2	86225602	NA	3.98	2.35	0.090	[15]
cg22891070	19	46801642	HIF3A	1.64	1.05	0.120	[16]
cg08857797	17	40927699	VPS25	3.59	2.33	0.125	[15]
cg06876354	2	121020189	RALB	7.28	4.76	0.126	[15]
cg15871086	18	56526595	NA	4.08	2.86	0.155	[15]
cg07814318	15	31624584	KLF13	3.64	2.60	0.161	[16]
cg04816311	7	1066650	C7orf50	2.07	1.98	0.295	[15]
cg04927537	17	76976091	LGALS3BP	1.95	1.87	0.297	[15]
cg04869770	1	164561550	PBX1	2.46	2.50	0.325	[15]
cg25178683	17	76976267	LGALS3BP	2.23	2.38	0.350	[15]
cg20954977	2	232260116	B3GNT7	1.65	1.93	0.391	[15]
cg18568872	15	90606494	ZNF710	2.41	3.55	0.497	[15]
cg00863378	16	56549757	BBS2	1.37	2.51	0.584	[15]
cg17560136	8	21915510	EPB49	1.18	2.64	0.654	[15]
cg13708645	12	121974305	KDM2B	0.67	1.71	0.697	[15]
cg15695155	12	121973871	KDM2B	0.81	3.44	0.813	[15]
cg27614723	15	92399897	SLCO3A1	0.81	4.02	0.840	[15]
cg09664445	17	2612406	CLUH	−0.86	5.28	0.871	[16]
cg18307303	5	158757456	IL12B	−0.24	3.39	0.943	[15]

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ISSN: 1868-7083

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