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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs

Fig. 4

Functional follow-up of top-ranked pan-cancer DMPs. Adjusted whole blood DNA methylation profiles compared to adjusted gene expression levels for (a) cg21046959 in blood and ILMN_1809352 (PRL) in LCLs, and (b) cg27094856 in blood and ILMN_1701877 (AXL) in skin. Data are obtained from 283 healthy middle-aged females and lines represent the least squares regression fit. c Enrichment analysis of genomic annotation categories within the 500 top-ranked cancer DMPs. The bars indicate the difference in proportion of DMPs compared to the remainder of probes used in the study in the corresponding genomic annotation class. Nominally significant results were obtained for the ‘enhancer’ category (P = 0.03)

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Clinical Epigenetics

ISSN: 1868-7083

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