Fig. 2
Pan-cancer epigenome-wide results in 41 discordant MZ twin-pairs. a Manhattan plot of the epigenome-wide association results in 41 pan-cancer-discordant MZ twin-pairs, where each point represents the observed −log10 P value at a CpG-site. b Direction of association at the top-ranked signal cg02444695, near SASH1. Results are plotted using normalised unadjusted beta values of cancer-affected individuals (left) and healthy individuals (right). The lines connect co-twins in twin-pairs and indicate a consistent direction of the effect with an average of 0.7 % within twin-pairs with a range of 0.9 to 3.0 %. The three suggestive probes are included in Additional file 1. c Pan-cancer DMR at TIMM44. Results are plotted using adjusted DNA methylation values at each CpG site in the DMR for individuals affected by cancer (red) and healthy co-twins (blue). Smooth (LOESS) lines with standard error are plotted for both groups. The CpG site driving the signal is at chr19:8,008,850 (hg19)