Table 3 The top-ranked CpG sites which show changes in DNA methylation levels overtime in the discordant MZ twins
Probe ID | Co-twin mean | Asthma mean | Mean ∆β | P value | Hg19 | Relation to CpG island | Gene region feature category (UCSC) | Illumina gene annotation | Probe type | Gene annotation from GREAT (distance from TSS) |
|---|---|---|---|---|---|---|---|---|---|---|
cg26090469 | −0.0122 | 0.0341 | 0.0463 | 1.41E-06 | Chr5:132271449 |  | Body | AFF4 | II | AFF4 (+27904), LEAP2 (+62092) |
cg02181624 | 0.1204 | −0.0649 | −0.1854 | 1.68E-06 | Chr6:168716070 | N_Shelf | Body | DACT2 | II | FRMD1 (−236232), DACT2 (+4331) |
cg17199800 | −0.0902 | 0.0620 | 0.1522 | 9.47E-06 | Chr7:96632777 | N_Shore | Body | DLX6AS | II | DLX6 (−2512) |
cg21875946 | 0.0892 | −0.0276 | −0.1168 | 1.88E-05 | Chr1:206663985 |  | Body | IKBKE | II | RASSF5 (−16893), IKBKE (+20400) |
cg15691003 | 0.0082 | −0.0205 | −0.0287 | 3.26E-05 | Chr1:22351864 | N_Shore | Body; TSS200 | HSPC157 | II | CDC42 (−27255), CELA3B (+48447) |
cg02836325 | −0.1285 | −0.0153 | 0.1132 | 3.37E-05 | Chr17:76403955 |  | Body | PGS1 | II | PGS1 (+29221), DNAH17 (+169520) |
cg16789707 | −0.0958 | 0.0404 | 0.1362 | 4.33E-05 | Chr16:88767723 | S_Shelf | Body | RNF166 | II | SNAI3 (−14842), RNF166 (+5105) |
cg04313071 | 0.1063 | −0.0249 | −0.1312 | 4.33E-05 | Chr14:102685619 |  | Body | WDR20 | II | HSP90AA1 (−79534), MOK (+85911) |
cg23847069 | 0.1153 | −0.0057 | −0.1210 | 4.79E-05 | Chr17:2702204 |  | Body | RAP1GAP2 | I | RAP1GAP2 (+2473), OR1D5 (+264696) |
cg24293948 | 0.0646 | −0.0729 | −0.1375 | 5.04E-05 | Chr18:61670413 | S_Shore | Intergenic |  | II | SERPINB8 (+33151), LINC00305 (+95460) |
cg06367321 | 0.1110 | −0.0015 | −0.1125 | 5.14E-05 | Chr16:30125232 |  | TSS200; TSS1500 | LOC100271831; GDPD3 | I | GDPD3 (−355) |
cg06655665 | −0.1603 | −0.0359 | 0.1243 | 5.45E-05 | Chr2:38607629 | S_Shelf | Intergenic |  | II | ATL2 (−3198) |
cg25406011 | 0.1312 | −0.0175 | −0.1487 | 6.04E-05 | Chr11:1254421 | Island | Body | MUC5B | II | MUC5B (+10127), TOLLIP (+76470) |
cg25494605 | 0.0873 | −0.0652 | −0.1525 | 6.55E-05 | Chr5:173472097 |  | TSS1500 | HMP19 | II | HMP19 (−626) |
cg24664347 | −0.1381 | 0.0087 | 0.1468 | 6.88E-05 | Chr8:86841010 | S_Shore | TSS1500 | REXO1L2P | II | REXO1L1 (−51705), PSKH2 (+240840) |
cg18184910 | 0.2047 | 0.0402 | −0.1644 | 7.10E-05 | Chr6:47624247 |  | TSS200 | GPR111 | II | GPR111 (−78) |
cg00840341 | 0.1094 | 0.0131 | −0.0963 | 7.60E-05 | Chr16:17609453 |  | Intergenic |  | II | XYLT1 (−44716), AK310228 (+825170) |
cg14141399 | 0.2139 | −0.0312 | −0.2451 | 7.66E-05 | Chr19:52228048 |  | TSS1500 | HAS1 | II | HAS1 (−828) |
cg14179581 | −0.1193 | 0.0758 | 0.1951 | 7.74E-05 | Chr1:50881502 | Island | Intergenic |  | II | DMRTA2 (+7616), ELAVL4 (+306909) |
cg21209859 | −0.0892 | 0.0351 | 0.1242 | 7.78E-05 | Chr1:167682516 | N_Shore | Intergenic |  | II | CREG1 (−159461), MPZL1 (−8670) |
cg21187770 | 0.1265 | −0.0432 | −0.1697 | 8.57E-05 | Chr2:26205876 | S_Shore | TSS1500 | KIF3C | I | KIF3C (−434) |
cg01382502 | −0.1489 | −0.0279 | 0.1210 | 8.96E-05 | Chr16:22252504 |  | Body | EEF2K | II | POLR3E (−56236), EEF2K (+34913) |
cg09900436 | −0.1813 | 0.0363 | 0.2175 | 8.96E-05 | Chr20:58630954 |  | TSS200 | C20orf197 | II | CDH26 (+97484) |
cg16606561 | 0.2193 | 0.0631 | −0.1562 | 9.72E-05 | Chr20:824641 | N_Shore | 5′UTR; TSS1500 | FAM110A | II | FAM110A (+10286), ANGPT4 (+72318) |
cg15048437 | 0.0067 | −0.0159 | −0.0226 | 9.85E-05 | Chr19:37019614 | Island | TSS1500 | ZNF260 | I | ZNF260 (−367) |