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Table 3 The top-ranked CpG sites which show changes in DNA methylation levels overtime in the discordant MZ twins

From: Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins

Probe ID Co-twin mean Asthma mean Mean ∆β P value Hg19 Relation to CpG island Gene region feature category (UCSC) Illumina gene annotation Probe type Gene annotation from GREAT (distance from TSS)
cg26090469 −0.0122 0.0341 0.0463 1.41E-06 Chr5:132271449   Body AFF4 II AFF4 (+27904), LEAP2 (+62092)
cg02181624 0.1204 −0.0649 −0.1854 1.68E-06 Chr6:168716070 N_Shelf Body DACT2 II FRMD1 (−236232), DACT2 (+4331)
cg17199800 −0.0902 0.0620 0.1522 9.47E-06 Chr7:96632777 N_Shore Body DLX6AS II DLX6 (−2512)
cg21875946 0.0892 −0.0276 −0.1168 1.88E-05 Chr1:206663985   Body IKBKE II RASSF5 (−16893), IKBKE (+20400)
cg15691003 0.0082 −0.0205 −0.0287 3.26E-05 Chr1:22351864 N_Shore Body; TSS200 HSPC157 II CDC42 (−27255), CELA3B (+48447)
cg02836325 −0.1285 −0.0153 0.1132 3.37E-05 Chr17:76403955   Body PGS1 II PGS1 (+29221), DNAH17 (+169520)
cg16789707 −0.0958 0.0404 0.1362 4.33E-05 Chr16:88767723 S_Shelf Body RNF166 II SNAI3 (−14842), RNF166 (+5105)
cg04313071 0.1063 −0.0249 −0.1312 4.33E-05 Chr14:102685619   Body WDR20 II HSP90AA1 (−79534), MOK (+85911)
cg23847069 0.1153 −0.0057 −0.1210 4.79E-05 Chr17:2702204   Body RAP1GAP2 I RAP1GAP2 (+2473), OR1D5 (+264696)
cg24293948 0.0646 −0.0729 −0.1375 5.04E-05 Chr18:61670413 S_Shore Intergenic   II SERPINB8 (+33151), LINC00305 (+95460)
cg06367321 0.1110 −0.0015 −0.1125 5.14E-05 Chr16:30125232   TSS200; TSS1500 LOC100271831; GDPD3 I GDPD3 (−355)
cg06655665 −0.1603 −0.0359 0.1243 5.45E-05 Chr2:38607629 S_Shelf Intergenic   II ATL2 (−3198)
cg25406011 0.1312 −0.0175 −0.1487 6.04E-05 Chr11:1254421 Island Body MUC5B II MUC5B (+10127), TOLLIP (+76470)
cg25494605 0.0873 −0.0652 −0.1525 6.55E-05 Chr5:173472097   TSS1500 HMP19 II HMP19 (−626)
cg24664347 −0.1381 0.0087 0.1468 6.88E-05 Chr8:86841010 S_Shore TSS1500 REXO1L2P II REXO1L1 (−51705), PSKH2 (+240840)
cg18184910 0.2047 0.0402 −0.1644 7.10E-05 Chr6:47624247   TSS200 GPR111 II GPR111 (−78)
cg00840341 0.1094 0.0131 −0.0963 7.60E-05 Chr16:17609453   Intergenic   II XYLT1 (−44716), AK310228 (+825170)
cg14141399 0.2139 −0.0312 −0.2451 7.66E-05 Chr19:52228048   TSS1500 HAS1 II HAS1 (−828)
cg14179581 −0.1193 0.0758 0.1951 7.74E-05 Chr1:50881502 Island Intergenic   II DMRTA2 (+7616), ELAVL4 (+306909)
cg21209859 −0.0892 0.0351 0.1242 7.78E-05 Chr1:167682516 N_Shore Intergenic   II CREG1 (−159461), MPZL1 (−8670)
cg21187770 0.1265 −0.0432 −0.1697 8.57E-05 Chr2:26205876 S_Shore TSS1500 KIF3C I KIF3C (−434)
cg01382502 −0.1489 −0.0279 0.1210 8.96E-05 Chr16:22252504   Body EEF2K II POLR3E (−56236), EEF2K (+34913)
cg09900436 −0.1813 0.0363 0.2175 8.96E-05 Chr20:58630954   TSS200 C20orf197 II CDH26 (+97484)
cg16606561 0.2193 0.0631 −0.1562 9.72E-05 Chr20:824641 N_Shore 5′UTR; TSS1500 FAM110A II FAM110A (+10286), ANGPT4 (+72318)
cg15048437 0.0067 −0.0159 −0.0226 9.85E-05 Chr19:37019614 Island TSS1500 ZNF260 I ZNF260 (−367)
  1. Ranked by P value
  2. DMPs differentially methylated positions, MZ monozygotic, GREAT Genomic Regions Enrichment of Annotations Tool, TSS transcription start site, UCSC University of California Santa Cruz