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Table 1 The top-ranked DMPs in asthma-discordant MZ twins

From: Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins

Probe ID Co-twin mean Asthma mean Mean ∆β P value Empirical P value Hg19 Relation to CpG island Gene region feature category (UCSC) Illumina gene annotation Probe type Gene annotation from GREAT (distance from TSS)
cg03284554 0.178 0.218 0.041 6.87E-06 <0.0001 Chr8:43113670 N_Shore TSS1500 HGSNAT II HGSNAT (−1078)
cg01496463 0.761 0.795 0.034 1.80E-05 0.0002 Chr12:3262908   3′UTR TSPAN9 II PRMT8 (−207777), TSPAN9 (+206127)
cg04373937 0.836 0.859 0.023 4.26E-05 <0.0001 Chr14:29622576   Intergenic   II G2E3 (−475503), PRKD1 (−155927)
cg14688104 0.035 0.038 0.003 4.29E-05 0.0001 Chr8:99508617 Island 1stExon; 5′UTR KCNS2 I KCNS2 (+192)
cg08158233 0.244 0.192 −0.052 5.36E-05 0.0001 Chr8:37470214   Intergenic   II ZNF703 (−202244), KCNU1 (+709215)
cg17269596 0.581 0.637 0.056 5.49E-05 0.0004 Chr1:243061735 N_Shelf Intergenic   II FAM36A (−3526)
cg14299157 0.813 0.756 −0.058 5.59E-05 <0.0001 Chr9:137272770 N_Shelf Intergenic   II PPP1R26 (−238698), OLFM1 (+165861)
cg21201551 0.747 0.779 0.032 5.90E-05 0.0001 Chr1:31404820 S_Shelf Intergenic   II PUM1 (−93670), NKAIN1 (+80500)
cg16414472 0.503 0.414 −0.089 6.05E-05 0.0002 Chr11:67866681   Body LRP5 I PPP6R3 (−118080), LRP5 (+29998)
cg01431063 0.057 0.072 0.014 8.92E-05 <0.0001 Chr10:115850893 Island Intergenic   II TDRD1 (−78125), ADRB1 (+57098)
cg01048931 0.071 0.084 0.013 9.42E-05 <0.0001 Chr7:55639931 Island Body VOPP1 I VOPP1 (+268)
  1. Ranked by P value. Empirical P value = (number of permutations which are at least as significant as the true result (P < 0.0001) divided by the number of permutations performed (n =10000))
  2. DMPs differentially methylated positions, MZ monozygotic, GREAT Genomic Regions Enrichment of Annotations Tool, TSS transcription start site, UCSC University of California Santa Cruz genome browser