Table 1 The top-ranked DMPs in asthma-discordant MZ twins
Probe ID | Co-twin mean | Asthma mean | Mean ∆β | P value | Empirical P value | Hg19 | Relation to CpG island | Gene region feature category (UCSC) | Illumina gene annotation | Probe type | Gene annotation from GREAT (distance from TSS) |
|---|---|---|---|---|---|---|---|---|---|---|---|
cg03284554 | 0.178 | 0.218 | 0.041 | 6.87E-06 | <0.0001 | Chr8:43113670 | N_Shore | TSS1500 | HGSNAT | II | HGSNAT (−1078) |
cg01496463 | 0.761 | 0.795 | 0.034 | 1.80E-05 | 0.0002 | Chr12:3262908 |  | 3′UTR | TSPAN9 | II | PRMT8 (−207777), TSPAN9 (+206127) |
cg04373937 | 0.836 | 0.859 | 0.023 | 4.26E-05 | <0.0001 | Chr14:29622576 |  | Intergenic |  | II | G2E3 (−475503), PRKD1 (−155927) |
cg14688104 | 0.035 | 0.038 | 0.003 | 4.29E-05 | 0.0001 | Chr8:99508617 | Island | 1stExon; 5′UTR | KCNS2 | I | KCNS2 (+192) |
cg08158233 | 0.244 | 0.192 | −0.052 | 5.36E-05 | 0.0001 | Chr8:37470214 |  | Intergenic |  | II | ZNF703 (−202244), KCNU1 (+709215) |
cg17269596 | 0.581 | 0.637 | 0.056 | 5.49E-05 | 0.0004 | Chr1:243061735 | N_Shelf | Intergenic |  | II | FAM36A (−3526) |
cg14299157 | 0.813 | 0.756 | −0.058 | 5.59E-05 | <0.0001 | Chr9:137272770 | N_Shelf | Intergenic |  | II | PPP1R26 (−238698), OLFM1 (+165861) |
cg21201551 | 0.747 | 0.779 | 0.032 | 5.90E-05 | 0.0001 | Chr1:31404820 | S_Shelf | Intergenic |  | II | PUM1 (−93670), NKAIN1 (+80500) |
cg16414472 | 0.503 | 0.414 | −0.089 | 6.05E-05 | 0.0002 | Chr11:67866681 |  | Body | LRP5 | I | PPP6R3 (−118080), LRP5 (+29998) |
cg01431063 | 0.057 | 0.072 | 0.014 | 8.92E-05 | <0.0001 | Chr10:115850893 | Island | Intergenic |  | II | TDRD1 (−78125), ADRB1 (+57098) |
cg01048931 | 0.071 | 0.084 | 0.013 | 9.42E-05 | <0.0001 | Chr7:55639931 | Island | Body | VOPP1 | I | VOPP1 (+268) |