Fig. 2

Differentially methylated CpG sites in fusion-positive versus fusion-negative PCa. a Manhattan plot of DNA methylation. The horizontal axis shows the chromosomes. A 10,000-bp “gap” was added between each chromosome to aid visualization. The dashed line represents the P value that corresponds to the FDR Q-value threshold for statistical significance of 0.00001. In total, 19,281 hypermethylated and 8595 hypomethylated CpGs reached statistical significance. The frequency of all evaluated and hyper- and hypomethylated CpG sites by b gene region and c epigenetic region. Genetic and epigenetic locations are based on Illumina annotation. Statistically significant differences are highlighted; *P value <0.05, **<0.01, or ***<0.001