Fig. 4From: Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer ADAMTS19 hypermethylation incidence in primary tumors of different origins in tumors from our collection (a) and from the TCGA datasets (b). In blue are ADAMTS19 hypermethylated cases. A higher incidence is found in gastrointestinal cancers compared to ovary and breast cancers (p = 5.2 × 10−7, OR = 2.9, CI = (1.9–4.7), Fisher’s exact test). c ADAMTS19 hypermethylation associates with mucinous phenotype in CRC and ovarian cancers (p = 0.023 and p = 4 × 10−16, respectively, Fisher’s exact test). The three ovarian cancer cases with ADAMTS19 hypermethylation in the no mucinous group were the only three clear-cell adenocarcinomasBack to article page