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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer

Fig. 4

ADAMTS19 hypermethylation incidence in primary tumors of different origins in tumors from our collection (a) and from the TCGA datasets (b). In blue are ADAMTS19 hypermethylated cases. A higher incidence is found in gastrointestinal cancers compared to ovary and breast cancers (p = 5.2 × 10−7, OR = 2.9, CI = (1.9–4.7), Fisher’s exact test). c ADAMTS19 hypermethylation associates with mucinous phenotype in CRC and ovarian cancers (p = 0.023 and p = 4 × 10−16, respectively, Fisher’s exact test). The three ovarian cancer cases with ADAMTS19 hypermethylation in the no mucinous group were the only three clear-cell adenocarcinomas

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