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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer

Fig. 2

Methylation analysis of the 3.5 Mb region of chromosome 5 surrounding the ADAMTS19 TSS in colorectal normal samples (upper heatmap) and tumors (middle heatmap) from 35 CRC patients. Columns and rows in the heatmaps represent Illumina HM450K probes and tissue samples, respectively. Samples are ordered according to the methylation level of the ADAMTS19 CGI. The lower heatmap shows the somatic difference in methylation between tumor samples and their matching normal samples. In this region, there are ten CpG islands (gray bars), corresponding to the promoters of SLC12A2, FBN2, SLC27A6, ISOC1, ADAMTS19, CHSY3, HINT1, LYRM7, and CDC42SE2 genes, as well as an intergenic CGI overlapping with a CTCF binding site (indicated by an asterisk). The lower triangle shows the correlations between every pair of probes. Only correlations with r 2 > 0.25 (p < 0.01) are shown. The areas corresponding to the correlations with ADAMTS19 CGI are indicated with dashed line rectangles

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Clinical Epigenetics

ISSN: 1868-7083

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