Table 1 Clinical data for PC patients represented on the radical prostatectomy tissue microarray
| Â | 546 RP patients included on TMA | 311 RP patients for whom a 5hmC score could be evaluated in malignant cores | 178 ERG positive RP patients for whom a 5hmC score could be evaluated in malignant cores | 133 ERG negative RP patients for whom a 5hmC score could be evaluated in malignant cores |
|---|---|---|---|---|
Age at RP, median (range) | 64 (36–77) | 63 (36–76) | 63 (48–74) | 63 (36–76) |
Pathological Gleason score | ||||
 =6, n (%) | 178 (32.6 %) | 88 (28 %) | 62 (35 %) | 26 (20 %) |
 =7, n (%) | 270 (49.5 %) | 172 (55 %) | 98 (55 %) | 74 (56 %) |
 ≥8, n (%) | 98 (17.9 %) | 51 (16 %) | 18 (10 %) | 33 (25 %) |
Pathological T stage (n) | ||||
 ≤pT2c, n (%) | 363 (66.5 %) | 205 (66 %) | 116 (65 %) | 89 (67 %) |
 ≥pT3a, n (%) | 182 (33.3 %) | 105 (34 %) | 62 (35 %) | 43 (32 %) |
 Unknown, n (%) | 1 (0.2 %) | 1 (<1 %) | 0 (0.0 %) | 1 (1 %) |
Pre-operative PSA | ||||
 PSA ≤10 ng/ml, n (%) | 222 (40.7 %) | 132 (42 %) | 83 (47 %) | 49 (37 %) |
 PSA >10 ng/ml, n (%) | 324 (59.3 %) | 179 (58 %) | 95 (53 %) | 84 (63 %) |
Surgical margin status | ||||
 Negative, n (%) | 174 (31.9 %) | 211 (68 %) | 122 (69 %) | 89 (67 %) |
 Positive, n (%) | 366 (67.0 %) | 95 (31 %) | 52 (29 %) | 43 (32 %) |
 Unknown, n (%) | 6 (1.1 %) | 5 (2 %) | 4 (2 %) | 1 (1 %) |
Lymph node status | ||||
 Positive, n (%) | 0 (0.0 %) | 0 (0.0 %) | 0 (0.0 %) | 0 (0.0 %) |
 Negative, n (%) | 366 (67.0 %) | 98 (32 %) | 57 (32 %) | 41 (31 %) |
 Unknown, n (%) | 180 (33.0 %) | 213 (68 %) | 121 (68 %) | 92 (69 %) |
 Median follow-up, months (range) | 79.7 (0–157.5) | 79.8 (12.2–157.5) | 80.4 (12.3–157.5) | 78.7 (12.2–140.9) |
 PSA recurrence, n (%) | 236 (43.2 %) | 143 (46 %) | 83 (46.6 %) | 60 (45 %) |
 No PSA recurrence, n (%) | 310 (56.8 %) | 168 (54 %) | 95 (53.4 %) | 73 (55 %) |
ERG status (determined by IHC) | ||||
 Positive, n (%) | 289 (52.9 %) | 178 (57 %) | 178 (100 %) | 0 (0.0 %) |
 Negative, n (%) | 242 (44.3 %) | 133 (43 %) | 0 (0.0 %) | 133 (100 %) |
 Unknown, n (%) | 14 (2.6 %) | 0 (0.0 %) | 0 (0.0 %) | 0 (0.0 %) |