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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Loss of DNA methylation at imprinted loci is a frequent event in hepatocellular carcinoma and identifies patients with shortened survival

Fig. 3

Aberrations of DNA methylation at imprinted loci and global DNA methylation levels. Loss of methylation at imprinted loci is accompanied by reduced DNA methylation at LINE-1 sequences which serves as a surrogate marker for global DNA methylation level [21]. DNA methylation at LINE-1 sequences is significantly lower in the subgroup with subtle loss of methylation. The difference is even more pronounced in the subgroup displaying severe loss of methylation at imprinted loci. ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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