Fig. 1

A representative result of methylation specific PCR (MSP) in the subtelomeric region on Chr. 7q (a), 8q (b), 18p (c), 21q (d), and XpYp (e). M and U refers to the amplification from the methylation- and unmethylation-specific primers respectively. Representative patients were identified by numbers. Chr. 7q subtelomere was partially methylated, and methylation level did not change significantly between the control and glioma patients. Chr.8q subtelomere was also partially methylated, but the methylation ratio increased significantly among the glioma patients. Chr. 18p subtelomere in majority of the non-glioma patients was noticeably amplified with U primers. However, distinct M-specific amplification was observed among the glioma patients. In contrast, subtelomeres of Chr. 21q and XpYp were mostly unmethylated in the non-glioma patients but showed significant increase in methylation level among the glioma patients