Table 2 Nucleosome epigenetic feature, AUC, and sensitivity at 90 % specificity
From: Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer
NuQ® assay | Cancer vs. healthy and benign | Cancer vs. healthy | ||
|---|---|---|---|---|
AUC | Sensitivity (%) | AUC | Sensitivity (%) | |
H3K4Me2 | 0.52 | 0 | 0.53 | 0 |
mH2A1.1 | 0.58 | 16 | 0.64 | 40 |
H3K9(Ac) | 0.61 | 12 | 0.69 | 44 |
H3K27Me3 | 0.64 | 40 | 0.68 | 40 |
H4Pan(Ac) | 0.67 | 24 | 0.71 | 36 |
H2AZ | 0.68 | 28 | 0.72 | 36 |
5-Methylcytosine (5MC) | 0.70 | 40 | 0.72 | 40 |
H2AK119Ub | 0.70 | 36 | 0.78 | 60 |
H3K9Me3 | 0.77 | 28 | 0.81 | 28 |