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Table 1 Clinical characteristics of subjects

From: The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women

  Never-obese Obesea P b
n 14 15  
Age (years) 45 ± 11 46 ± 11 0.93
Weight (kg) 69 ± 7 115 ± 11 3.4 × 10−13
BMI (kg/m2) 25.2 ± 2.5 41.4 ± 4.5 4.1 × 10−12
Waist to hip ratio 0.85 ± 0.06 0.98 ± 0.06 5.0 × 10−6
Systolic blood pressure (mmHg) 123 ± 19 138 ± 22 0.073
Diastolic blood pressure (mmHg) 74 ± 6 85 ± 9 6.0 × 10−4
P-Glucose (mmol/l) 5.1 ± 0.4 5.7 ± 1.2 0.053
P-Insulin (mU/l) 4.6 ± 2.3 16.0 ± 10.3 3.7 × 10−4
P-Cholesterol (mmol/l) 4.7 ± 1.0 4.9 ± 0.7 0.57
P-HDL Cholesterol (mmol/l) 1.5 ± 0.4 1.1 ± 0.3 0.0058
P-Triglycerides (mmol/l) 0.86 ± 0.72 1.67 ± 0.92 0.013
P-NEFA (mmol/l) 0.57 ± 0.17 0.83 ± 0.16 2.4 × 10−4
P-Apolipoprotein B (g/l) 0.83 ± 0.25 0.96 ± 0.25 0.19
P-Apolipoprotein A1 (g/l) 1.39 ± 0.22 1.19 ± 0.24 0.028
Mean fat cell volume (pl) 443 ± 169 994 ± 184 5.5 × 10−9
  1. aThree of the obese women had type 2 diabetes, of which two were treated with diet plus metformin, and one woman with diet alone. Nine were treated for hypertension and one patient had stable multiple sclerosis and did not receive any drugs
  2. bComparison of control and obese group with unpaired t test. Values are mean ± SD