Fig. 3
From: Triage of high-risk human papillomavirus-positive women by methylated POU4F3
Proposed cervical cancer screening strategy using hrHPV assay and POU4F3 methylation analysis as a triage test. In this proposed scenario, HCII hrHPV DNA assay is used as the primary screening test, where women without hrHPV infection undergo follow-up 3 to 5Â years later. Samples from women with hrHPV infection undergo POU4F3 methylation analysis, where women having positive POU4F3 methylation are referred for colposcopy. Additionally, women with a positive hrHPV assay but negative POU4F3 methylation may repeat HPV assay and DNA methylation analysis 1Â year later