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Table 1 RT-PCR data for a single dose of a panel of HKMT inhibitor compounds

From: Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

Entry   Compound KRT17 FBXO32 JMJD3 EZH2
1 Hit HKMTI-1-005 4.05 3.65 3.12 0.63
2 Hit HKMTI-1-022 4.28 29.4 11.56 0.21
3 Hit HKMTI-1-11 6.95 33.25 6.25 0.22
4 G9ai BIX01294 1.06 3.34 2.7 0.87
5 G9ai UNC0638a 1.1 5.5 3.4 0.4
6 EZH2i GSK343 0.9 1.2 1.0 1.0
7 Negative HKMTI-1-002 0.66 1.12 1.57 0.86
8 Negative HKMTI-1-012 1.32 1.06 0.9 1.38
9 Negative HKMTI-1-013 0.78 0.93 0.87 0.13
  1. RNA levels for target genes are normalised against the housekeeping gene GAPDH, and shown is the fold increase compared to the mock treated sample
  2. aUNC0638 treatment at 7.5 μM, all other compounds given at 10 μM