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Table 1 Clinical characteristics of individuals from the Saguenay–Lac-Saint-Jean asthma familial collection

From: DNA methylation signature of interleukin 1 receptor type II in asthma

Characteristics

All individuals (n = 93)

Controls (n = 25)

Asthmaticsa and/or atopicsb (n = 68)

Sex ratio (M:F)

1:1.2

1:1.8

1:1

Mean age, year (range)

15 (3–46)

14 (3–44)

15 (4–46)

<16 years old, n (%)

64 (69)

18 (72)

46 (68)

FEV1, % predicted (SD)c

62 (40)

63 (40)

62 (40)

PC20, mg/ml (SD)d

8.2 (4.3)

15.3 (3.4)

6.8 (4.4)

Serum IgE, μg/l (SD)e

109 (5)

36 (4)

157 (4)

Asthma, n (%)a

47 (51)

NA

47 (69)

Atopy, n (%)b

47 (51)

NA

47 (69)

With asthma, n (%)a

26 (28)

NA

26 (38)

  1. aPresent asthma or past documented clinical history of asthma. Data available for all individuals
  2. bDefined as having at least one positive response on the skin prick test (wheal diameter ≥3 mm at 10 min). Data available for all individuals
  3. cFEV1 = mean and standard deviation (SD) calculated for forced expiratory volume in 1 s for 67 individuals (16 controls, 51 asthmatic and/or atopic individuals)
  4. dPC20 = geometric mean and SD of provocative methacholine concentration inducing 20 % decline in FEV1 calculated for 58 individuals (14 controls, 44 asthmatic and/or atopic individuals)
  5. eIgE = geometric mean and SD of serum immunoglobulin (Ig) E level concentration calculated for 80 individuals (20 controls, 60 asthmatic and/or atopic individuals)