Fig. 6

Trend in methylation differences at X chromosome between 46,XX and 47,XXY. a MeDIP data of the X chromosome in all four groups; all data are aligned to the transcription start site (TSS): 7 kb upstream and 3 kb downstream. b Illumina 27K methylation values; the data are divided into 10 pins depending on the degree of X inactivation of the corresponding locus (according to Carrel and Willard [2]); average methylation at each pin is represented in the plot and the significant p value between female and Klinefelter samples at 0/9 is shown; all other comparisons between either female and Klinefelter or between male and Turners were not significant. c Detailed pyrosequencing data on two X-linked loci (TEF3 and SLC35A2) showing the differences in average methylation between female and Klinefelter samples