Table 1 Characteristics of sample series
Prospective series | Retrospective series | |
|---|---|---|
No. of individuals or specimens | No. of individuals or specimens | |
Lynch syndrome | ||
• Individuals with mutation in | ||
MLH1 | 39 (71 %) | 33 (77 %) |
MSH2 | 13 (24 %) | 7 (16 %) |
MSH6 | 3 (5 %) | 3 (7 %) |
Total | 55 | 43 |
• Colorectal specimens | ||
Normal colonic mucosa | 55 | 24 |
Hyperplastic polyp | 10 | – |
Low dysplasia adenoma | 5 | 27 |
High dysplasia adenoma | 3 | 13 |
Carcinoma | 3 | 20 |
Total | 76 | 84 |
Familial adenomatous polyposis | ||
• Individuals with mutation in | ||
APC | 22 (100 %) | – |
• Colorectal specimens | ||
Normal colonic mucosa | 22 | – |
Adenoma (all dysplasia grades) | 23 | – |
Carcinoma | – | – |
Total | 45 | – |