Figure 2
![Figure 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13148-015-0086-0/MediaObjects/13148_2015_86_Fig2_HTML.gif)
Ingenuity pathway analysis (IPA) identifies deregulation of MYC and EZH2/polycomb in vHMEC. (A) The two most significant gene expression pathways identified by IPA involve deregulation of the proto-oncogene MYC and (B) the epigenetic regulator and member of the polycomb family, EZH2 (shading represents t statistic). (C) Gene set enrichment analysis demonstrates up-regulation of MYC targets and (D) down-regulation of polycomb target genes in vHMEC in a pattern identical to that reported in cancer.