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Figure 1 | Clinical Epigenetics

Figure 1

From: Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis

Figure 1

Summary of gene expression changes in vHMEC. (A) Hierarchical clustering of the PAM50 expression profile of vHMEC and a breast cancer cohort [GEO:GSE2034] classifies vHMEC (black box) into the basal-like molecular subtype of breast cancer. (B) The expression profile of differentially expressed genes in HMEC (light blue) and early and late vHMEC (orange and red, respectively) clusters samples into separate HMEC and vHMEC clusters. (C) The t-statistic of genes that gain (orange) or lose expression (red) in vHMEC is stable in early and late vHMEC indicating the vHMEC expression pattern is stable even after extended time in culture.

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Clinical Epigenetics

ISSN: 1868-7083

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