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Table 2 Testing of inflammation-induced miRNA candidates identified in vitro in human subcutaneous adipose tissue (AT) samples

From: Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants

  Inflamed (5% MCM)/control adipocytes Inflamed (10 ng/ml LPS)/control macrophages Obese AT/post-weight loss
  Expression Supernatant Expression Supernatant Human AT ( n= 9)
  Ratio P value Ratio P value Ratio P value Ratio P value % change P value
miR-146b Only detectable in the SN of inflamed MAs      −88 <0.0001
miR-146a      4.96 <0.0001    −69.6 0.002
miR-376c Only detectable in inflamed MAs      −78 0.002
miR-221 1.98 0.027 15.43 0.002 0.49 0.034    −51.3 0.003
miR-223    4.87 0.001      −74.3 0.004
miR-411 Only detectable in inflamed MAs      −62.2 0.004
miR-155 5.01 0.015 4.03 <0.0001 2.48 0.001    −54.4 0.005
miR-19b    19.76 <0.0001 0.61 0.009    −72.7 0.006
miR-19a Only detectable in the SN of inflamed MAs 0.49 0.032 2.02 0.034 −73.4 0.008
RNU48        0.22 0.015 −45 0.009
miR-222 2.51 0.044 6.07 0.001      −48.9 0.028
miR-193b    0.37 0.014      −44.8 0.039
miR-766 Undetectable in inflamed MAs      182 0.084
let-7a        0.12 0.014 6.1 0.276
miR-145      0.19 0.005 0.14 0.032 −26.9 0.228
miR-92a    7.73 0.002    1.75 0.007 −21.3 0.327
miR-572 Undetectable in inflamed MAs      −7.6 0.413
miR-378        4.95 0.014 −41 0.78
  1. Results from nine morbid obese participants before and after surgery-induced weight loss (post-weight loss, see Additional file 2: Table S2 for additional details). Results assessed were compared by paired t-test. ‘Detectable’ refers to <35 Cts, while ‘undetectable’ indicates ≥35 Cts in all biological replicates (n = 3), as explained above. Italics for significant results.