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Table 1 Significant modulation of miRNAs expressed and/or secreted (supernatant) by M1 macrophages upon lipopolysaccharide (LPS, 10 ng/ml) stimuli and mature adipocytes treated or not with macrophages LPS-conditioned medium (MCM, 5%)

From: Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants

  Expression Supernatant
Ratio P value Ratio P value
  Inflamed (5% MCM)/control mature adipocytes (MAs)
IL-6 mRNA 78.56 0.004   
TNFα mRNA 14 <0.0001   
miR-155 5.01 0.015 4.03 <0.0001
miR-132 3.17 0.011   
miR-222 2.51 0.044 6.07 0.001
miR-221 1.98 0.027 15.43 0.002
miR-17 1.60 0.031   
miR-31 1.59 0.028   
miR-93 1.59 0.031   
miR-345 1.58 0.033   
miR-422a 0.50 0.028   
miR-19b    19.76 <0.0001
miR-92a    7.73 0.002
miR-342-3p    6.08 0.027
miR-223    4.87 0.001
miR-20a    4.86 0.001
miR-199a-3p    0.47 0.029
miR-214    0.39 0.026
miR-193b    0.37 0.014
miR-152    0.24 0.023
  Inflamed (10 ng/ml LPS)/control macrophages (M1)
IL-6 mRNA 17.74 0.002   
TNFα mRNA 4.90 0.001   
miR-146a 4.96 <0.0001   
miR-155 2.48 0.001   
miR-149 0.62 0.012   
miR-27a 0.61 0.009   
miR-19b 0.61 0.009   
miR-124 0.61 0.011   
miR-221 0.49 0.034   
miR-19a 0.49 0.032 2.02 0.034
miR-425* 0.41 0.011   
miR-181a 0.37 0.015   
miR-145 0.19 0.005 0.14 0.032
miR-378    4.95 0.014
miR-345    3.24 0.013
miR-132    2.92 0.021
miR-212    2.56 0.013
miR-106a    2.03 0.035
miR-25    1.93 0.016
miR-24    1.77 0.005
miR-92a    1.75 0.007
miR-30a-5p    1.55 0.010
miR-30e-3p    0.39 0.002
RNU48    0.22 0.015
miR-15b    0.20 0.037
let-7a    0.12 0.014
  1. Results assessed were compared by Student t-test. Italics for significant results.