Table 1 Significant modulation of miRNAs expressed and/or secreted (supernatant) by M1 macrophages upon lipopolysaccharide (LPS, 10 ng/ml) stimuli and mature adipocytes treated or not with macrophages LPS-conditioned medium (MCM, 5%)

IL-6 mRNA

78.56

0.004

TNFα mRNA

14

<0.0001

miR-155

5.01

0.015

4.03

<0.0001

miR-132

3.17

0.011

miR-222

2.51

0.044

6.07

0.001

miR-221

1.98

0.027

15.43

0.002

miR-17

1.60

0.031

miR-31

1.59

0.028

miR-93

1.59

0.031

miR-345

1.58

0.033

miR-422a

0.50

0.028

miR-19b

19.76

<0.0001

miR-92a

7.73

0.002

miR-342-3p

6.08

0.027

miR-223

4.87

0.001

miR-20a

4.86

0.001

miR-199a-3p

0.47

0.029

miR-214

0.39

0.026

miR-193b

0.37

0.014

miR-152

0.24

0.023

IL-6 mRNA

17.74

0.002

TNFα mRNA

4.90

0.001

miR-146a

4.96

<0.0001

miR-155

2.48

0.001

miR-149

0.62

0.012

miR-27a

0.61

0.009

miR-19b

0.61

0.009

miR-124

0.61

0.011

miR-221

0.49

0.034

miR-19a

0.49

0.032

2.02

0.034

miR-425*

0.41

0.011

miR-181a

0.37

0.015

miR-145

0.19

0.005

0.14

0.032

miR-378

4.95

0.014

miR-345

3.24

0.013

miR-132

2.92

0.021

miR-212

2.56

0.013

miR-106a

2.03

0.035

miR-25

1.93

0.016

miR-24

1.77

0.005

miR-92a

1.75

0.007

miR-30a-5p

1.55

0.010

miR-30e-3p

0.39

0.002

RNU48

0.22

0.015

miR-15b

0.20

0.037

let-7a

0.12

0.014