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Table 3 Hypomethylated and transcriptionally induced genes ( n = 30) in HCC as compared to cancer-free tissue

From: DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

Cell communication (6) a

Gene Name

P value

Coefficient

ASAP1

0.015

1.3

CD34

0.03

1.5

GLDN

0.006

1.2

MYBPC1

0.026

1.4

RIMS2

0.03

2.2

TRIM55

0.0002

2.8

Immune response (8) a

Gene Name

P value

Coefficient

CD200

0.038

2.1

CTLA4

0.018

2.2

CXCL10

0.048

1.6

DCSTAMP

0.03

1.1

LRRC69

0.015

1.0

NOX4

0.018

1.6

SSX6

0.03

3.2

SSX8

0.019

3.4

Transport (2) a

Gene Name

P value

Coefficient

KIF4A

0.006

2.2

SLC7A11

0.006

2.6

Metabolic and cellular process (3) a

  

Gene Name

P value

Coefficient

DTNA

0.044

2.0

HIST1H4F

0.022

1.7

SPINK1

0.0004

4.2

Cell growth, cell cycle and apoptosis (4) a

Gene Name

P value

Coefficient

ESM1

0.002

2.0

GINS4

0.013

1.4

LTA

0.009

1.0

MAP2

0.009

1.0

Miscellaneous (7) a

Gene Name

P value

Coefficient

C15orf42

0.002

1.9

FBXO32

0.003

2.1

KIAA1688

0.001

1.6

POTEA

0.009

1.7

POTEC

0.018

1.5

VCX2

0.017

2.0

VCX3A

0.012

2.4

  1. aNumber of genes hypermethylated and transcriptionally repressed. Coefficient and P value refer to gene expression data.