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Table 2 List of top 12 literature-derived concepts most significantly associated with NEARS

From: Polycomb-mediated silencing in neuroendocrine prostate cancer

NEARS literature-defined Oncomine concept analysis
Rank Concept PcG-related P value Q value Odds ratio
1 CBX8 target genes in human embryonic fibroblasts X 1.2E-15 9.6E-12 5.0
2 Upregulated genes in neutrophils compared to other blood cells   7.4E-13 3.8E-10 6.5
3 Downregulated in human embryonic stem cells vs differentiated counterparts   1.3E-13 5.8E-10 6.9
4 Downregulated genes in prostate cancer after androgen ablation therapy   4.9E-12 1.5E-8 20.5
5 SUZ12 target genes in human embryonic stem cells X 5.2E-12 1.5E-8 6.4
6 Trimethylated H3K27 target genes in human embryonic stem cells X 2.5E-11 4.8E-8 5.9
7 DrugBank targets - FDA approved   5.6E-11 1.0E-8 12.3
8 Upregulated genes in weakly invasive colon cancer cells   5.6E-11 1.0E-7 12.3
9 Polycomb group target genes in human embryonic stem cells X 7.0E-10 8.4E-7 7.1
10 Upregulated genes in prostate cancer cells in response to synthetic androgen R1881   9.1E-10 9.5E-7 11.0
11 EED target genes in human embryonic fibroblasts X 1.8E-9 1.8E-6 5.4
12 Trimethylated H3K27 target genes in human embryonic fibroblasts X 3.4E-9 2.8E-6 3.7