Table 2 List of top 12 literature-derived concepts most significantly associated with NEARS
From: Polycomb-mediated silencing in neuroendocrine prostate cancer
NEARS literature-defined Oncomine concept analysis | |||||
|---|---|---|---|---|---|
Rank | Concept | PcG-related | P value | Q value | Odds ratio |
1 | CBX8 target genes in human embryonic fibroblasts | X | 1.2E-15 | 9.6E-12 | 5.0 |
2 | Upregulated genes in neutrophils compared to other blood cells | Â | 7.4E-13 | 3.8E-10 | 6.5 |
3 | Downregulated in human embryonic stem cells vs differentiated counterparts | Â | 1.3E-13 | 5.8E-10 | 6.9 |
4 | Downregulated genes in prostate cancer after androgen ablation therapy | Â | 4.9E-12 | 1.5E-8 | 20.5 |
5 | SUZ12 target genes in human embryonic stem cells | X | 5.2E-12 | 1.5E-8 | 6.4 |
6 | Trimethylated H3K27 target genes in human embryonic stem cells | X | 2.5E-11 | 4.8E-8 | 5.9 |
7 | DrugBank targets - FDA approved | Â | 5.6E-11 | 1.0E-8 | 12.3 |
8 | Upregulated genes in weakly invasive colon cancer cells | Â | 5.6E-11 | 1.0E-7 | 12.3 |
9 | Polycomb group target genes in human embryonic stem cells | X | 7.0E-10 | 8.4E-7 | 7.1 |
10 | Upregulated genes in prostate cancer cells in response to synthetic androgen R1881 | Â | 9.1E-10 | 9.5E-7 | 11.0 |
11 | EED target genes in human embryonic fibroblasts | X | 1.8E-9 | 1.8E-6 | 5.4 |
12 | Trimethylated H3K27 target genes in human embryonic fibroblasts | X | 3.4E-9 | 2.8E-6 | 3.7 |