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Figure 8 | Clinical Epigenetics

Figure 8

From: Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy

Figure 8

Myocytes from FSHD1-affected subjects are epigenetically poised to express DUX4-fl . Myocytes from five family cohorts (03, 07, 09, 17, and 19) of clinically affected FSHD1 subjects (A) and healthy first-degree relative controls (U) were treated in parallel with Decitabine (ADC), TSA, ADC + TSA (ADC TSA), or left untreated (NT). DUX4-fl expression was analyzed by qRT-PCR and normalized to levels of 18S RNA. Data are plotted as fold expression relative to the untreated control sample for each cohort and summarized in the table, lower right. All assays were repeated three times and each qRT-PCR was performed in triplicate.

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Clinical Epigenetics

ISSN: 1868-7083

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