CpG genomic location a | Gene | Fertile control methylation fraction (mean ± SD) | Donor oocyte ART methylation fraction (mean ± SD) | Infertile ART methylation fraction (mean ± SD) | One-way ANOVA ( P -value) b | Tukey’s HSD test | |
---|---|---|---|---|---|---|---|
Donor oocyte ART vs fertile control ( P -value) | Female infertile ART vs fertile control ( P -value) | ||||||
chr12:121824850 | CCDC62 | 0.162 ± 0.096 | 0.101 ± 0.087 | 0.131 ± 0.078 | 0.018 | <0.01 | nsc |
chr12:121824853 | CCDC62 | 0.165 ± 0.095 | 0.102 ± 0.084 | 0.135 ± 0.078 | 0.014 | <0.01 | ns |
chr11:122214681 | CRTAM | 0.555 ± 0.069 | 0.547 ± 0.098 | 0.556 ± 0.073 | 0.887 | - | - |
chr17:30783625 | FLJ10260 | 0.586 ± 0.137 | 0.653 ± 0.107 | 0.606 ± 0.115 | 0.106 | - | - |
chr5:115326619 | FLJ90650 | 0.087 ± 0.086 | 0.119 ± 0.096 | 0.141 ± 0.114 | 0.022 | ns | ns |
chr5:115326640 | FLJ90650 | 0.100 ± 0.081 | 0.126 ± 0.113 | 0.144 ± 0.120 | 0.094 | - | - |
chr5:115326626 | FLJ90650 | 0.095 ± 0.089 | 0.147 ± 0.132 | 0.157 ± 0.131 | 0.019 | ns | ns |
chr5:115326614 | FLJ90650 | 0.098 ± 0.091 | 0.113 ± 0.112 | 0.137 ± 0.124 | 0.175 | - | - |
chr7:50816700 | GRB10 | 0.417 ± 0.079 | 0.360 ± 0.096 | 0.452 ± 0.057 | <0.001 | <0.01 | ns |
chr7:50816682 | GRB10 | 0.245 ± 0.062 | 0.205 ± 0.062 | 0.268 ± 0.064 | <0.001 | <0.01 | ns |
chr7:50816674 | GRB10 | 0.269 ± 0.057 | 0.247 ± 0.064 | 0.292 ± 0.057 | 0.005 | ns | ns |
chr7:50816802 | GRB10 | 0.620 ± 0.070 | 0.613 ± 0.078 | 0.629 ± 0.050 | 0.529 | - | - |
chr17:70368047 | GRIN2C | 0.167 ± 0.075 | 0.091 ± 0.048 | 0.109 ± 0.065 | <0.001 | <0.01 | <0.01 |
chr17:70368057 | GRIN2C | 0.108 ± 0.050 | 0.067 ± 0.033 | 0.079 ± 0.041 | <0.001 | <0.01 | <0.05 |
chr11:1975300 | H19 | 0.456 ± 0.027 | 0.443 ± 0.060 | 0.472 ± 0.055 | 0.031 | ns | ns |
chr5:131908379 | IL5 | 0.710 ± 0.056 | 0.724 ± 0.053 | 0.712 ± 0.057 | 0.605 | - | - |
chr1:234113562 | LYST | 0.650 ± 0.055 | 0.649 ± 0.036 | 0.626 ± 0.068 | 0.069 | - | - |
chr7:129913072 | MEST | 0.374 ± 0.093 | 0.372 ± 0.082 | 0.378 ± 0.094 | 0.954 | - | - |
chr7:129913081 | MEST | 0.464 ± 0.105 | 0.465 ± 0.103 | 0.477 ± 0.114 | 0.793 | - | - |
chr7:129913254 | MEST | 0.278 ± 0.093 | 0.293 ± 0.084 | 0.294 ± 0.095 | 0.635 | - | - |
chr7:129913259 | MEST | 0.302 ± 0.110 | 0.326 ± 0.084 ± | 0.321 ± 0.102 | 0.532 | - | - |
chr15:21483466 | NDN | 0.179 ± 0.076 | 0.245 ± 0.139 | 0.212 ± 0.110 | 0.041 | <0.05 | ns |
chr15:21483463 | NDN | 0.235 ± 0.101 | 0.310 ± 0.182 | 0.275 ± 0.137 | 0.075 | - | - |
chr5:140777470 | PCDHGB7 | 0.390 ± 0.157 | 0.389 ± 0.167 | 0.425 ± 0.145 | 0.404 | - | - |
chr5:140777464 | PCDHGB7 | 0.312 ± 0.152 | 0.313 ± 0.156 | 0.337 ± 0.145 | 0.627 | - | - |
chr5:140777418 | PCDHGB7 | 0.183 ± 0.103 | 0.189 ± 0.120 | 0.213 ± 0.116 | 0.337 | - | - |
chr10:48448112 | PTPN20B | 0.199 ± 0.134 | 0.274 ± 0.148 | 0.247 ± 0.159 | 0.094 | - | - |
chr10:48448103 | PTPN20B | 0.239 ± 0.140 | 0.314 ± 0.176 | 0.288 ± 0.162 | 0.115 | - | - |
chr10:48448106 | PTPN20B | 0.215 ± 0.136 | 0.278 ± 0.176 | 0.254 ± 0.146 | 0.191 | - | - |
chr10:48448108 | PTPN20B | 0.259 ± 0.175 | 0.351 ± 0.184 | 0.296 ± 0.161 | 0.107 | - | - |
chr10:48448115 | PTPN20B | 0.295 ± 0.185 | 0.385 ± 0.206 | 0.343 ± 0.181 | 0.144 | - | - |
chr15:22620469 | SNRPN | 0.091 ± 0.032 | 0.098 ± 0.043 | 0.098 ± 0.054 | 0.690 | - | - |
chr15:22644337 | SNRPN | 0.287 ± 0.109 | 0.299 ± 0.125 | 0.298 ± 0.123 | 0.867 | - | - |
chr15:22644327 | SNRPN | 0.269 ± 0.097 | 0.274 ± 0.151 | 0.243 ± 0.109 | 0.358 | - | - |
chr17:33179448 | TCF2 | 0.545 ± 0.059 | 0.538 ± 0.077 | 0.537 ± 0.067 | 0.804 | - | - |
chr17:33179450 | TCF2 | 0.479 ± 0.067 | 0.463 ± 0.081 | 0.476 ± 0.068 | 0.663 | - | - |
chr18:27424926 | TTR | 0.660 ± 0.036 | 0.637 ± 0.049 | 0.646 ± 0.049 | 0.094 | - | - |