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Table 2 One-way ANOVA and Tukey’s HSD test to assess methylation fraction mean differences in ART (infertile ART and donor oocyte ART) and control groups

From: DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility

CpG genomic location a

Gene

Fertile control methylation fraction (mean ± SD)

Donor oocyte ART methylation fraction (mean ± SD)

Infertile ART methylation fraction (mean ± SD)

One-way ANOVA ( P -value) b

Tukey’s HSD test

Donor oocyte ART vs fertile control ( P -value)

Female infertile ART vs fertile control ( P -value)

chr12:121824850

CCDC62

0.162 ± 0.096

0.101 ± 0.087

0.131 ± 0.078

0.018

<0.01

nsc

chr12:121824853

CCDC62

0.165 ± 0.095

0.102 ± 0.084

0.135 ± 0.078

0.014

<0.01

ns

chr11:122214681

CRTAM

0.555 ± 0.069

0.547 ± 0.098

0.556 ± 0.073

0.887

-

-

chr17:30783625

FLJ10260

0.586 ± 0.137

0.653 ± 0.107

0.606 ± 0.115

0.106

-

-

chr5:115326619

FLJ90650

0.087 ± 0.086

0.119 ± 0.096

0.141 ± 0.114

0.022

ns

ns

chr5:115326640

FLJ90650

0.100 ± 0.081

0.126 ± 0.113

0.144 ± 0.120

0.094

-

-

chr5:115326626

FLJ90650

0.095 ± 0.089

0.147 ± 0.132

0.157 ± 0.131

0.019

ns

ns

chr5:115326614

FLJ90650

0.098 ± 0.091

0.113 ± 0.112

0.137 ± 0.124

0.175

-

-

chr7:50816700

GRB10

0.417 ± 0.079

0.360 ± 0.096

0.452 ± 0.057

<0.001

<0.01

ns

chr7:50816682

GRB10

0.245 ± 0.062

0.205 ± 0.062

0.268 ± 0.064

<0.001

<0.01

ns

chr7:50816674

GRB10

0.269 ± 0.057

0.247 ± 0.064

0.292 ± 0.057

0.005

ns

ns

chr7:50816802

GRB10

0.620 ± 0.070

0.613 ± 0.078

0.629 ± 0.050

0.529

-

-

chr17:70368047

GRIN2C

0.167 ± 0.075

0.091 ± 0.048

0.109 ± 0.065

<0.001

<0.01

<0.01

chr17:70368057

GRIN2C

0.108 ± 0.050

0.067 ± 0.033

0.079 ± 0.041

<0.001

<0.01

<0.05

chr11:1975300

H19

0.456 ± 0.027

0.443 ± 0.060

0.472 ± 0.055

0.031

ns

ns

chr5:131908379

IL5

0.710 ± 0.056

0.724 ± 0.053

0.712 ± 0.057

0.605

-

-

chr1:234113562

LYST

0.650 ± 0.055

0.649 ± 0.036

0.626 ± 0.068

0.069

-

-

chr7:129913072

MEST

0.374 ± 0.093

0.372 ± 0.082

0.378 ± 0.094

0.954

-

-

chr7:129913081

MEST

0.464 ± 0.105

0.465 ± 0.103

0.477 ± 0.114

0.793

-

-

chr7:129913254

MEST

0.278 ± 0.093

0.293 ± 0.084

0.294 ± 0.095

0.635

-

-

chr7:129913259

MEST

0.302 ± 0.110

0.326 ± 0.084 ±

0.321 ± 0.102

0.532

-

-

chr15:21483466

NDN

0.179 ± 0.076

0.245 ± 0.139

0.212 ± 0.110

0.041

<0.05

ns

chr15:21483463

NDN

0.235 ± 0.101

0.310 ± 0.182

0.275 ± 0.137

0.075

-

-

chr5:140777470

PCDHGB7

0.390 ± 0.157

0.389 ± 0.167

0.425 ± 0.145

0.404

-

-

chr5:140777464

PCDHGB7

0.312 ± 0.152

0.313 ± 0.156

0.337 ± 0.145

0.627

-

-

chr5:140777418

PCDHGB7

0.183 ± 0.103

0.189 ± 0.120

0.213 ± 0.116

0.337

-

-

chr10:48448112

PTPN20B

0.199 ± 0.134

0.274 ± 0.148

0.247 ± 0.159

0.094

-

-

chr10:48448103

PTPN20B

0.239 ± 0.140

0.314 ± 0.176

0.288 ± 0.162

0.115

-

-

chr10:48448106

PTPN20B

0.215 ± 0.136

0.278 ± 0.176

0.254 ± 0.146

0.191

-

-

chr10:48448108

PTPN20B

0.259 ± 0.175

0.351 ± 0.184

0.296 ± 0.161

0.107

-

-

chr10:48448115

PTPN20B

0.295 ± 0.185

0.385 ± 0.206

0.343 ± 0.181

0.144

-

-

chr15:22620469

SNRPN

0.091 ± 0.032

0.098 ± 0.043

0.098 ± 0.054

0.690

-

-

chr15:22644337

SNRPN

0.287 ± 0.109

0.299 ± 0.125

0.298 ± 0.123

0.867

-

-

chr15:22644327

SNRPN

0.269 ± 0.097

0.274 ± 0.151

0.243 ± 0.109

0.358

-

-

chr17:33179448

TCF2

0.545 ± 0.059

0.538 ± 0.077

0.537 ± 0.067

0.804

-

-

chr17:33179450

TCF2

0.479 ± 0.067

0.463 ± 0.081

0.476 ± 0.068

0.663

-

-

chr18:27424926

TTR

0.660 ± 0.036

0.637 ± 0.049

0.646 ± 0.049

0.094

-

-

  1. aCorresponds to genome build 36.1; bvalues in italics denote significance; cnot significant.