Figure 6
Longitudinal trends of the DNA methylation levels in six immune genes within 3 to 60 months after birth. DNA methylation levels are expressed as M value; each dot represents an individual. The dotted lines represent the 95% CI of the regression line; logfc = log fold change in methylation over time; pbonf = Bonferroni-corrected P value. IRF5 = interferon regulatory factor 5; NOD2 = nucleotide-binding oligomerization domain containing 2; IL18BP = interleukin 18 binding protein; PTGER4 = prostaglandin E receptor 4; TNFRSF8 = tumour necrosis factor receptor superfamily, member 8; HLA-B = major histocompatibility complex, class I, B.