Table 3 Correlations between methylation in sperm DNA within different H4K12ac-associated promoters, ejaculate parameters, and fertility rates
Promoter | Sperm concentration ( × 10 6 /ml) | Sperm motility | Sperm morphology | Fertility rate (ICSI) |
|---|---|---|---|---|
AFF4 | R = −0.25; P = 0.232 | R = −0.04; P = 0.821 | R = 0.08; P = 0.692 | R = −0.272; P = 0.18 |
NCOA6 | R = −0.07; P = 0.677 | R = 0.24; P = 0.183 | R = 0.15; P = 0.387 | R = 0.06; P = 0.72 |
RUVBL1 | R = −0.05; P = 0.767 | R = −0.03; P = 0.870 | R = −0.28; P = 0.138 | R = 0.36; P = 0.05 |
NSD1 | R = −0.32; P = 0.071 | R = −0.05; P = 0.976 | R = −0.17; P = 0.326 | R = 0.22; P = 0.21 |
USP9X | R = −0.03; P = 0.865 | R = 0.01; P = 0.943 | R = −0.39; P = 0.072 | R = 0.17; P = 0.42 |
POU2F | R = −0.30; P = 0.121 | R = −0.43; P = 0.023* | R = −0.24; P = 0.217 | R = −0.33; P = 0.08 |
Protamine | R = 0.41; P = 0.138 | R = 0.12; P = 0.689 | R = −0.12; P = 0.976 | R = 0.71; P = 0.003** |