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Table 3 Correlations between methylation in sperm DNA within different H4K12ac-associated promoters, ejaculate parameters, and fertility rates

From: Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients

Promoter Sperm concentration ( × 10 6 /ml) Sperm motility Sperm morphology Fertility rate (ICSI)
AFF4 R = −0.25; P = 0.232 R = −0.04; P = 0.821 R = 0.08; P = 0.692 R = −0.272; P = 0.18
NCOA6 R = −0.07; P = 0.677 R = 0.24; P = 0.183 R = 0.15; P = 0.387 R = 0.06; P = 0.72
RUVBL1 R = −0.05; P = 0.767 R = −0.03; P = 0.870 R = −0.28; P = 0.138 R = 0.36; P = 0.05
NSD1 R = −0.32; P = 0.071 R = −0.05; P = 0.976 R = −0.17; P = 0.326 R = 0.22; P = 0.21
USP9X R = −0.03; P = 0.865 R = 0.01; P = 0.943 R = −0.39; P = 0.072 R = 0.17; P = 0.42
POU2F R = −0.30; P = 0.121 R = −0.43; P = 0.023* R = −0.24; P = 0.217 R = −0.33; P = 0.08
Protamine R = 0.41; P = 0.138 R = 0.12; P = 0.689 R = −0.12; P = 0.976 R = 0.71; P = 0.003**
  1. Significant values when *P ≤ 0.05 and **P ≤ 0.01.