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Table 1 Summary of H4K12ac lacking promoters in spermatozoa of subfertile patients

From: Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients

Function of promoters depleted for H4K12ac binding in sperm chromatin of subfertile patients References
AFF4 AF4/FMR2 family member 4, AFF4-deficient mice male mice are sterile with azoospermia and their outcomes died in utero and neonatally with impaired embryonic development. Urano et al. [39]
NCOA6 Nuclear receptor co-activator 6; involved in the co-activation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR), and prostanoids (PPARs). Li and Xu [40]
RUVBL1 RuvB-like 1, TATA box-binding protein-interacting protein, component of the NuA4 histone acetyltransferase complex. Yamauchi et al. [41], Choudhary et al. [42]
NSD1 Histone methyltransferase, methylates ‘Lys-36’ of histone H3 and ‘Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription. Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome. Tatton-Brown and Weksberg [43], Crea [44], Baujat et al. [45]
EP300 Histone acetyltransferase p300; regulates transcription via chromatin remodeling. Zhang et al. [46]
LRP5 Low-density lipoprotein receptor-related protein 5; forms phosphorylated oligomer aggregates on Wnt-signaling. Required for posterior patterning of the epiblast during gastrulation. Joiner et al. [47]
POU2F1 POU domain, class 2, transcription factor 1. Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′) and activates the promoters of the genes for some small nuclear RNAs. Latchman [48]