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Table 3 Hypermethylated genes selected for pyrosequencing validation

From: Two independent epigenetic biomarkers predict survival in neuroblastoma

Genes Sign. probes Total probes P values Gene function
NNAT 3 7 0.018, 0.021, 0.032 Involved in the maturation or maintenance of the overall structure of the nervous system
TP73 3 12 0.004, 0.032, 0.047 Participates in the apoptotic response to DNA damage
CCND1 2 18 0.034, 0.048 Essential for the control of the cell cycle at the G1/S (start) transition
RUNX3 2 19 0.0004, 0.039 Tumor suppressor gene
CTSZ 1 7 0.037 May be involved in tumorigenesis and metastasis
DUSP2 1 2 0.012 Regulates cellular proliferation and differentiation
HPN 1 2 0.023 Plays an essential role in cell growth and maintenance of cell morphology
JAK2 1 1 0.036 Involved in cell cycle progression, apoptosis, mitotic recombination, genetic instability, and histone modifications
LRRC4 1 2 0.014 Significantly downregulated in primary brain tumors. The exact function of the protein encoded is unknown
MAGEA2 1 2 0.034 May play a role in embryonal development and tumor transformation or aspects of tumor progression
MGMT 1 26 0.031 Involved in DNA repair mechanisms
PAX8 1 2 0.008 Transcription factor. Mutations in this gene are associated with carcinogenesis
ECRG4 1 2 0.004 Antiapoptotic gene
RB1 1 21 0.048 Negative regulator of the cell cycle
TDGF1 1 2 0.037 Plays an essential role in embryonic development and tumor growth
TSPAN32 1 2 0.008 Is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5